Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies
To investigate the relationship between the integrity of the white matter, including the corticospinal tracts and the corpus callosum, with the recovery of lower extremity function in patients with cerebral stroke at the subacute and chronic stages.
|Study Design:||Observational Model: Case Control
Time Perspective: Retrospective
|Official Title:||Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies|
- clinical assessments, included balance, motor, walking,ADL, will be obtained for tests performed on D7, D30 and D90 [ Time Frame: D30, D90 and D180 post stroke onset ] [ Designated as safety issue: No ]
|Study Start Date:||August 2006|
|Study Completion Date:||July 2009|
|Primary Completion Date:||June 2009 (Final data collection date for primary outcome measure)|
Recent studies have provided strong evidence that motor recovery after adult ischemic stroke is a function of neural plasticity. Up to date, it remains largely unknown as to the relationship between the integrity of the subcortical white matter with the lower extremity function recovery. Given the fact that the white matter is more resistant to ischemia after acute stroke than the gray matter (Falcao et al., 2004) and that the intensity of white matter in stroke has been found to be much greater in many brain areas in stroke than in healthy controls (Wen et al., 2004), it is of interest to study how the integrity of the subcortical white matter, primarily the corticospinal tracts and the corpus callosum, contributes to the recovery of lower extremity function in subacute and chronic stroke with lesions involving different areas of the brain.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00407628
|School and Graduate Institute of Physical Therapy College of Medicine, National Taiwan University|
|Taipei, Taiwan, China|
|Study Chair:||Pei-Fang Tang, PhD||National Taiwan University Hospital|