Retinal Blood Flow and Microthrombi in Type 1 Diabetes
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|ClinicalTrials.gov Identifier: NCT00406991|
Recruitment Status : Completed
First Posted : December 4, 2006
Last Update Posted : October 30, 2015
The project aims to find mechanisms for the abnormal retinal blood flow that in diabetic patients often precedes any evidence of clinical retinopathy and may contribute to the development of retinopathy.
Specifically, the projects tests the hypothesis that reduced retinal blood flow found in young patients with type 1 diabetes reflects increased resistance in the small vessels of the retina caused by the formation of small blood clots, called microthrombi; and that antiplatelet agents normalize the reduced retinal blood flow.
|Condition or disease||Intervention/treatment||Phase|
|Diabetes Diabetic Retinopathy||Drug: aspirin Drug: clopidogrel||Phase 2|
The ultimate goal of this research is to contribute to the development of strategies to prevent diabetic retinopathy. This project will test the hypothesis that antiplatelet agents normalize the reduced blood flow observed early in the course of type 1 diabetes. If the hypothesis is proven correct, the results will indicate that the formation of small blood clots (microthrombi) occurs early in diabetic retinal vessels. In turn, because microthrombosis could readily account for the occlusive microangiopathy that causes the sight-threatening stages of diabetic retinopathy, the results will propose the desirability of antiplatelet therapy for the prevention of diabetic retinopathy.
We have three specific aims:
- To confirm that, under basal conditions, retinal blood flow measured with the laser Doppler method in a group of type 1 diabetic patients with no or minimal retinopathy differs from the flow measured in age- and sex-matched nondiabetic control subjects;
- To determine whether the response of retinal blood flow to low-dose aspirin (81 mg/day) administered for 2 months versus placebo, differs between type 1 diabetic patients with no or minimal retinopathy and age- and sex-matched nondiabetic control subjects;
- To determine whether in type 1 diabetic patients with no or minimal retinopathy the response of retinal blood flow to low-dose aspirin differs from the response to clopidogrel, a drug that interferes with platelet function downstream of the site of aspirin action.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||100 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Retinal Blood Flow and Microthrombi in Type 1 Diabetes|
|Study Start Date :||June 2003|
|Estimated Study Completion Date :||March 2006|
- Retinal blood flow
- Retinal arterial blood speed
- Retinal arterial diameter
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00406991
|United States, Massachusetts|
|Schepens Eye Research Institute|
|Boston, Massachusetts, United States, 02114|
|Principal Investigator:||Mara Lorenzi, MD||Schepens Eye Research Institute|