Prospective Randomized Trial Between WBRT Plus SRS Versus SRS Alone for 1-4 Brain Metastases
The purpose of this study is to determine if WBRT combined with SRS resulted in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death.
Procedure: Whole-Brain Radiation Therapy, Stereotactic Radiosurgery
|Study Design:||Observational Model: Defined Population
Time Perspective: Longitudinal
|Official Title:||Phase 3 Study of Whole Brain Radiation Therapy Plus Stereotactic Radiosurgery Versus Stereotactic Radiosurgery Alone for 1-4 Brain Metastases|
|Study Start Date:||October 1999|
|Estimated Study Completion Date:||April 2005|
Whole-Brain Radiation Therapy (WBRT) had been a mainstay in the treatment of brain metastases. However, treatment strategy which rely on Stereotactic Radiosurgery (SRS) has becoming popular in Japan. It is not well understood if the Whole-Brain Radiation Therapy (WBRT) combined with Stereotactic Radiosurgery (SRS) resulted in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death. In orer to determine the role of WBRT, we conducted prospective randomized trial between WBRT+SRS and SRS-alone for 1-4 brain metastatic patients.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00406835
|Hokkaido University School of Medicine|
|Sapporo, Hokkaido, Japan, 060-8638|
|Principal Investigator:||Hidefumi Aoyama, MD, PhD||Hokkaido University School of Medicine|
|Study Chair:||Hiroki Shirato, MD, PhD||Hokkaido University School of Medicine|
|Study Director:||Keiichi Nakagawa, MD, PhD||Tokyo University|