Inflammatory Markers in Exhaled Breath (Condensate) in Childhood Asthma
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|ClinicalTrials.gov Identifier: NCT00404976|
Recruitment Status : Completed
First Posted : November 29, 2006
Last Update Posted : November 29, 2006
Exhaled nitric oxide and inflammatory biomarkers in exhaled breath condensate may be useful to diagnose and monitor childhood asthma. Their ability to indicate an asthma diagnosis, and to assess asthma severity and control, is largely unknown.
To study 1) the ability of exhaled nitric oxide and inflammatory markers in exhaled breath condensate (nitrite, nitrate, hydrogen peroxide, 8-isoprostane, interferon-γ, tumor necrosis factor-α, interleukin-2,-4,-5,-10, acidity) to discriminate between childhood asthma and controls. 2) the ability of these biomarkers to indicate asthma severity and control.
114 Children were included: 64 asthmatics (10.7±3.0 years, 67.2% atopic) and 50 controls (10.0±0.4 years). Condensate was collected using a glass condenser
|Condition or disease|
|Asthma Healthy Children|
|Study Type :||Observational|
|Enrollment :||100 participants|
|Official Title:||Biomarkers in Exhaled Breath (Condensate) Indicate Presence, Severity and Control of Asthma|
|Study Start Date :||June 2004|
|Study Completion Date :||April 2005|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00404976
|University Hospital Maastricht|
|Maastricht, Netherlands, 6202AZ|
|Principal Investigator:||Charlotte M Robroeks, MD||Maastricht University Medical Center|
|Study Director:||Edward Dompeling, MD, PhD||Maastricht University Medical Center|
|Study Director:||Quirijn Jöbsis, MD, PhD||Maastricht University Medical Center|