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Effects of Peritendinous Corticosteroid Injections, Eccentric Training and Heavy Slow Resistance Training in Patellar Tendinopathy

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00404469
First Posted: November 28, 2006
Last Update Posted: May 22, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Bispebjerg Hospital
  Purpose
We will investigate the effect of peritendinous corticosteroid injections, eccentric training and heavy resistance training in male patellar tendinopathy patients. The purpose is to compare the clinical effect of these three treatments in a randomised controlled trial. Also we wish to investigate the treatment mechanisms responsible for the effectiveness of the three treatments.

Condition Intervention
Patellar Tendinopathy / Jumpers Knee Procedure: peritendinous corticosteroid injections Procedure: eccentric decline squat training Procedure: heavy slow resistance training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Peritendinous Corticosteroid Injections, Eccentric Training and Heavy Slow Resistance Training in Patellar Tendinopathy

Resource links provided by NLM:


Further study details as provided by Bispebjerg Hospital:

Enrollment: 39
Study Start Date: March 2006
Study Completion Date: November 2007
Arms Assigned Interventions
Active Comparator: CORT
Peritendinous corticosteroid injections at 0 and 4 weeks. 12 weeks total
Procedure: peritendinous corticosteroid injections
1 ml of40mg/ml methylprednisolone acetate at 0 and 4 weeks. 2 week observational
Experimental: ECC
12 weeks of eccentric unilateral decline squats
Procedure: eccentric decline squat training
eccentric decline unilateral squats performed twice daily. for 12 weeks
Experimental: HSR
Heavy slow resistance training. 3/week. 12 weeks
Procedure: heavy slow resistance training
Heavy slow resistance training for knee extensors. 3/week. total of 12 weeks

Detailed Description:

3 interventions groups as described above (n=13 in each group) 12 weeks intervention period. Clinical assessments before and after intervention: VAS, VISA, Tendon thickness, Doppler us activity.

Before and after intervention tendon biopsies will be taken and analyzed for crosslinks and fibril diameter. Also tendon mechanical properties will be measured. Tendon and muscle structural properties will be measured with MRI.

Treatment satisfaction will be stated after intervention period.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical patellar tendinopathy pain.
  • Tendon swelling
  • Hypoechoic
  • Doppler activity in tendon

Exclusion Criteria:

  • Previous knee surgery
  • diabetes
  • arthritis
  • previous steroid injections
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00404469


Locations
Denmark
Institute of Sports Medicine Copenhagen. Dept 8 1st floor. Bispebjerg Hospital
Copenhagen, Denmark, 2400
Sponsors and Collaborators
Bispebjerg Hospital
Investigators
Principal Investigator: Mads Kongsgaard, PhD., MSc. Institute of Sports Medicine, Copenhagen
  More Information

ClinicalTrials.gov Identifier: NCT00404469     History of Changes
Other Study ID Numbers: Patellar tendinopathy
First Submitted: November 27, 2006
First Posted: November 28, 2006
Last Update Posted: May 22, 2008
Last Verified: May 2008

Additional relevant MeSH terms:
Tendinopathy
Muscular Diseases
Musculoskeletal Diseases
Tendon Injuries
Wounds and Injuries