Protocol Chronic Obstructive Pulmonary Disease
The main objective of the study is to evaluate the predictive factors of the endothelial function to the waning of an acute exacerbation in COPD. It will act to do a multivariate analysis to determine the respective weight of the parameters of the systemic inflammation, of the oxidative stress of the functional respiratory parameters and then functional respiratory parameters.
In exacerbated Chronic Obstructive Pulmonary Disease (COPD) patients, there is augmentation of hypoxia and the obstructive ventilatory disorders is more important. This is correlated with an increase in C-reactive Protein (CRP) and of inflammatory cytokines and oxidative stress. It has been demonstrated that there is an endothelial dysfunction in answer to hypoxia. Since the exacerbated COPD patients are hypoxic in most cases , we suppose they have an endothelial dysfunction during exacerbation. So we think we will find an augmentation of vascular resistances ,shown by a peripheral arterial tone too high. And this, certainly, play a part in physiopathology of the COPD exacerbation.
Chronic Obstructive Pulmonary Disease
Acute Respiratory Failure
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Predictive Factors of Endothelial Function in Chronic Obstructive Disease Patients at the End of a Acute Exacerbation.|
- peripheral arterial tone [ Time Frame: once a year ] [ Designated as safety issue: No ]
- Muscle strength measurements [ Time Frame: once a year ] [ Designated as safety issue: No ]
- biological markers of inflammation and oxidative stress [ Time Frame: once a year ] [ Designated as safety issue: No ]
- respiratory function measurements [ Time Frame: once a year ] [ Designated as safety issue: No ]
- Determine the relationship between the RMI measurements and the cardiovascular risk [ Time Frame: once during the study ] [ Designated as safety issue: No ]
- Determine the relationship between the hospitalizations for decompensation and the initial value of endothelial function [ Time Frame: study time frame ] [ Designated as safety issue: No ]
- Determine the relationship between the RMI measurements and the COPD severity [ Time Frame: once during the study ] [ Designated as safety issue: No ]
- Determine the prevalence of nocturnal non-dipping blood pressure in COPD patients [ Time Frame: once a year ] [ Designated as safety issue: No ]
- pulse wave velocity measurement [ Time Frame: once a year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||January 2007|
|Estimated Study Completion Date:||February 2021|
|Estimated Primary Completion Date:||February 2021 (Final data collection date for primary outcome measure)|
Exacerbated COPD patients
Patients with exacerbated COPD
Stable COPD patients
Patients with stable COPD
We want to judge the improvement of the endothelial function remotely to the acute exacerbation (6 weeks). And then we would like to correlate this improvement with the variations of oxidative stress, muscle strength, respiratory function and systemic inflammation.
We also would like to find a relation between the new hospitalizations for respiratory exacerbation and the initial value of endothelial function.
Then we would like to evaluate the relationship between the cardiovascular risk and the COPD severity.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00404430
|France : Laboratoire EFCR - Functional Cardio-Respiratory Exploration Laboratory|
|Grenoble, Isere, France, 38043|
|Principal Investigator:||Jean-Louis JP Pépin, ProfessorPhD||University Hospital, Grenoble|