A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Lupus Nephritis Previously Enrolled in Study U2970g
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This is a Phase III, multicenter, extension study to evaluate the safety of rituximab administered on a scheduled basis approximately every 6 months. All subjects who complete their Week 52 visit in Study U2970g will be eligible for this study, as long as the inclusion and exclusion criteria are met.
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Ages Eligible for Study:
16 Years to 75 Years (Child, Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Ability and willingness to provide written informed consent and comply with the requirements of the study protocol
Participation in Study U2970g and completion of the Week 52 visit in that study
For subjects of reproductive potential (males and females), use of a reliable means of contraception throughout their study participation
Discontinuation or withdrawal from Study U2970g or failure to complete the Week 52 visit
Any safety concern potentially attributable to rituximab that in the investigator's opinion may jeopardize subject safety
In the investigator's opinion, lack of any clinical improvement by Week 52 in Study U2970g and for whom the proposed therapy would represent risk without benefit
Current thrombocytopenia or at high risk for developing clinically significant bleeding or organ dysfunction requiring therapies such as plasmapheresis or acute blood or platelet transfusions
Lack of peripheral venous access
Pregnancy or lactation
History of severe, allergic, or anaphylactic reactions to humanized or murine monoclonal antibodies
Significant new or uncontrolled disease in any organ system not related to SLE (e.g., poorly controlled chronic obstructive pulmonary disease or asthma, cardiovascular disease, accelerated hypertension, major depression) that in the investigator's opinion would preclude subject participation
Known active infection of any kind (excluding fungal infection of nail beds), any major episode of infection requiring hospitalization, or treatment with IV antibiotics within 4 weeks of a study drug infusion or oral antibiotics within 2 weeks of a study drug infusion
History of cancer, including solid tumors, hematologic malignancies, and carcinoma in situ
Major surgery within 4 weeks prior to screening
Intolerance or contraindication to oral or IV corticosteroids
Lipase > 2 x the upper limit of normal (ULN)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) > 2.5 x the ULN
Amylase levels > 2 x the ULN
Absolute neutrophil counts < 1.5 x 10^3/uL
History of positive hepatitis B surface antigen or hepatitis C serology
Hemoglobin < 7 g/dL unless caused by autoimmune hemolytic anemia resulting from SLE
Platelet count < 10,000/uL
Receipt of a live vaccine within 28 days prior to treatment