Clinical and Pathophysiological Description of Ocular Ischemic Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00403195
Recruitment Status : Completed
First Posted : November 23, 2006
Last Update Posted : September 10, 2012
Rigshospitalet, Denmark
University Hospital, Gentofte, Copenhagen
Information provided by (Responsible Party):
Peter Kofoed, Glostrup University Hospital, Copenhagen

Brief Summary:
The purpose of this study is to characterize the disease Ocular Ischemic Syndrome.

Condition or disease
Retinal Degeneration Diabetic Retinopathy

Detailed Description:
The disease Ocular Ischemic Syndrome (OIS) is not a well described entity. It occurs after a long-standing period of extremely low blood supply to the retina caused by atherosclerosis of the carotid arteries. In this study we will analyze why OIS is developed in some patients and not developed in others. The patients with OIS will be thorough examined and will be compared with 1) a control group of healthy people and 2) with control group of patients with diabetic retinopathy. Furthermore the impact of vascular surgery on OIS will be analyzed.

Study Type : Observational
Actual Enrollment : 13 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Pathophysiological Analysis of Ocular Ischemic Syndrome and the Response to Vascular Surgery
Study Start Date : November 2006
Actual Primary Completion Date : January 2009
Actual Study Completion Date : January 2009

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with the disease ocular ishemic syndrome. Patients will be screened through vascular surgery departments.

Inclusion Criteria:

  • Ocular ischemic syndrome

Exclusion Criteria:

  • Any other active ocular disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00403195

Department of Ophthalmology, Glostrup Hospital, University of Copenhagen
Glostrup, Denmark, 2600
Sponsors and Collaborators
Glostrup University Hospital, Copenhagen
Rigshospitalet, Denmark
University Hospital, Gentofte, Copenhagen
Study Director: Michael Larsen, Professor

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Peter Kofoed, Principal investigator, Glostrup University Hospital, Copenhagen Identifier: NCT00403195     History of Changes
Other Study ID Numbers: OIS
First Posted: November 23, 2006    Key Record Dates
Last Update Posted: September 10, 2012
Last Verified: September 2012

Keywords provided by Peter Kofoed, Glostrup University Hospital, Copenhagen:
Ocular Ischemic Syndrome

Additional relevant MeSH terms:
Diabetic Retinopathy
Retinal Degeneration
Retinal Diseases
Eye Diseases
Diabetic Angiopathies
Vascular Diseases
Cardiovascular Diseases
Diabetes Complications
Diabetes Mellitus
Endocrine System Diseases