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Evaluating the Association Between Pericardial Fat and Coronary Heart Disease - Ancillary to MESA

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00402922
First Posted: November 23, 2006
Last Update Posted: January 25, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Jingzhong Ding, PhD, Wake Forest University Health Sciences
  Purpose
Coronary heart disease (CHD) is the leading cause of death in the United States. One common risk factor for CHD is obesity. The presence of certain types of fat over others is more commonly associated with the development of CHD. This study will use data from a previous study to examine the association between pericardial fat, a type of fat that surrounds the heart, and CHD.

Condition
Coronary Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Pericardial Fat and Subclinical and Clinical Measures of Coronary Heart Disease - Ancillary to MESA

Resource links provided by NLM:


Further study details as provided by Jingzhong Ding, PhD, Wake Forest University Health Sciences:

Primary Outcome Measures:
  • Coronary heart disease events [ Time Frame: 6 years ]

Enrollment: 6814
Study Start Date: August 2006
Study Completion Date: May 2012
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Detailed Description:

CHD is caused by a narrowing of the small blood vessels that supply blood and oxygen to the heart. It usually results from atherosclerosis, a condition in which deposits of fat, cholesterol, and other substances build up along the inner walls of arteries. Risk factors for CHD include tobacco use, high blood pressure, diabetes, and obesity. Visceral fat, the type of fat found in the abdomen and surrounding vital organs, is considered a greater risk factor for CHD than subcutaneous fat, the type of fat found directly below the skin. Pericardial fat, the fat surrounding the heart, is similar to visceral fat, and may be particularly damaging because of its lipotoxicity effects and its ability to trigger inflammation in the coronary arteries. Increased amounts of pericardial fat may therefore accelerate the development of atherosclerosis and CHD. The purpose of this study is to evaluate the relationship between pericardial fat and the development of CHD.

This study will use previously collected data from participants in the Multi-Ethnic Study of Atherosclerosis (MESA) study, a study that examined characteristics of the subclinical, or the early stages of, cardiovascular disease in individuals. There will be no study visits specifically for this study. Participants' study data and computed tomography (CT) scans will be analyzed to determine the following: 1) the presence of pericardial fat and subclinical CHD at study entry; 2) changes in pericardial fat levels and plaque formation; and 3) the presence of pericardial fat and CHD at a 6-year follow-up visit.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years to 84 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Participant in the MESA study
Criteria

Inclusion Criteria:

  • Participant in the MESA study
  • Had a baseline and 6-year follow-up CT scan as part of the MESA study

Exclusion Criteria:

  • Participant did not have a baseline or 6 year follow-up CT in the MESA study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00402922


Sponsors and Collaborators
Wake Forest University
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
Principal Investigator: Jingzhong Ding, MD, PhD Wake Forest University Health Sciences
  More Information

Responsible Party: Jingzhong Ding, PhD, Associate Professor, Wake Forest University Health Sciences
ClinicalTrials.gov Identifier: NCT00402922     History of Changes
Other Study ID Numbers: 1358
R01HL085323-01 ( U.S. NIH Grant/Contract )
First Submitted: November 22, 2006
First Posted: November 23, 2006
Last Update Posted: January 25, 2017
Last Verified: January 2017

Keywords provided by Jingzhong Ding, PhD, Wake Forest University Health Sciences:
Coronary Heart Disease

Additional relevant MeSH terms:
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Cardiovascular Diseases
Vascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases