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Abnormalities of B Lymphocytes During Systemic Lupus

This study has been completed.
Information provided by:
University Hospital, Strasbourg, France Identifier:
First received: November 16, 2006
Last updated: August 7, 2008
Last verified: August 2008
Previous experimental data strongly suggest that B lymphocytes have intrinsic abnormalities during lupus in mice spontaneously affected by the disease. This study tries to define these abnormalities by looking at the gene expression profile of purified B lymphocytes from patients with non active systemic lupus , compared with the gene expression profile of purified B lymphocytes from healthy donnors.

Condition Intervention
Systemic Lupus Erythematosus
Procedure: Blood samples

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Official Title: Phenotypic Characteristics and Transcriptomas of B Lymphocytes During Non Active Systemic Lupus Erythematosus

Resource links provided by NLM:

Further study details as provided by University Hospital, Strasbourg, France:

Estimated Enrollment: 30
Study Start Date: April 2004

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion criteria:

  • non active systemic lupus

Exclusion criteria:

  • immunosuppressive drugs
  • more than 10 mg of prednisone per day
  Contacts and Locations
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Please refer to this study by its identifier: NCT00401141

Service d'Immunologie Clinique et VIH - Hôpital Civil
Strasbourg, France, 67091
Sponsors and Collaborators
University Hospital, Strasbourg, France
Study Director: Jean-Louis Pasquali, MD Hôpitaux Universitaires de Strasbourg
  More Information Identifier: NCT00401141     History of Changes
Other Study ID Numbers: 3156
Study First Received: November 16, 2006
Last Updated: August 7, 2008

Keywords provided by University Hospital, Strasbourg, France:
Systemic lupus
B lymphocytes

Additional relevant MeSH terms:
Lupus Erythematosus, Systemic
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases processed this record on April 28, 2017