Interpersonal Psychotherapy for Depressed Adolescents Engaging in Non-suicidal Self-injury (IPT-ASI)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00401102
Recruitment Status : Completed
First Posted : November 17, 2006
Results First Posted : January 28, 2013
Last Update Posted : January 28, 2013
MINT: Mental Health Initiative
Information provided by (Responsible Party):
New York State Psychiatric Institute

Brief Summary:
The purpose of this study is to examine the feasibility of using Interpersonal Psychotherapy for Depressed Adolescents (IPT-A) to treat adolescents who are experiencing symptoms of depression and are engaging in non-suicidal self-injurious behaviors. The trial will include recruiting 10 particpants, administering 12-sessions of individual IPT-A, and determining how the IPT-A protocol needs to be amended to adequately address the self-injury in addition to depression.

Condition or disease Intervention/treatment Phase
Depression Self-injurious Behavior Behavioral: Interpersonal Psychotherapy for Depressed Adolescents Phase 1

Detailed Description:
Engagement in non-suicidal self-injury (NSSI), purposefully harming oneself without the conscious intent to die such as cutting or burning, is pervasive among adolescents. Lifetime prevalence estimates among community samples of high school students range from 13.0% to 23.2%. Despite the significance of this public health problem, there are no known interventions that successfully reduce the frequency of NSSI or prevent NSSI in adolescents. The goal of the current study is to develop an effective psychosocial intervention for NSSI among adolescents who are engaging in self-injury and have a depressive disorder. Specifically, we will amend Interpersonal Psychotherapy for Depressed Adolescents (IPT-A), a psychotherapy that has demonstrated efficacy in treating depressed adolescents (Mufson et al., 1994, 1999, 2004), for use with adolescents with depression who are engaging in NSSI, with the ultimate goal of curing the depression and NSSI. Ten participants will be administered IPT-A and assessed several times throughout the course of the trial. It is expected that IPT-A will be a useful treatment for co-morbid depression and self-injury, although adaptations to the protocol will likely be needed to address the behavioral aspect of the self-injury. Data analyses will be descriptive in nature and involve examining the individual trajectories of depression and NSSI over time. The data obtained from the current study will lay the groundwork for an ultimate randomized controlled trial in which we plan to compare IPT-A versus nondirective supportive therapy in the treatment of co-morbid depression and NSSI.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 10 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: An Open-clinical Trial of Interpersonal Psychotherapy for Depressed Adolescents (IPT-A) for Depressed Adolescents Engaged in Non-suicidal Self-injury
Study Start Date : November 2006
Actual Primary Completion Date : September 2009
Actual Study Completion Date : September 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Self-harm

Arm Intervention/treatment
Interpersonal psychotherapy
All participants received interpersonal psychotherapy adapted for self-injury
Behavioral: Interpersonal Psychotherapy for Depressed Adolescents
Open clinical trial of IPT-ASI for depressed and self-injuring adolescents, 12-18 years. Goal is to assess feasibility of using IPT-A protocol for teens with co-morbid depression and self-injury. All eligible participants receive 12 weeks of individual IPT-ASI with optional monthly booster sessions. IPT-ASI is a psychosocial intervention that focuses on the importance of interpersonal relationships in relation to psychological functioning. The first phase (4 weeks) includes a review of depression and self-injury symptoms, psycho-education about depression and self-injury, and a detailed assessment of the patient's important interpersonal relationships. The middle phase (weeks 5-9) involves interpersonal skill building, including communication skills, affect identification and expression, problem solving. The final phase ( weeks 10-12) involves review of skills, generalization of skills to other relationships, termination.

Primary Outcome Measures :
  1. CGI [ Time Frame: 1 week ]
  2. C-GAS [ Time Frame: 1 month ]
  3. CDRS [ Time Frame: 1 week ]
  4. Self-Injurious Thoughts and Behaviors Interview [ Time Frame: 8 weeks ]
  5. Self-injury Monitoring Card [ Time Frame: 1 month ]

Secondary Outcome Measures :
  1. Beck Depression Inventory [ Time Frame: 2 weeks ]
  2. Multidimensional Anxiety Scale for Children [ Time Frame: recently ]

Information from the National Library of Medicine

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Ages Eligible for Study:   12 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. 12 to 18 years of age
  2. Diagnosis of MDD, Dysthymic Disorder, Depressive Disorder NOS, Adjustment Disorder with depressed Mood
  3. Non-suicidal self-injurious behavior
  4. CDRS >= 36
  5. C-GAS <= 65
  6. English speaking patient
  7. One English speaking caregiver -

Exclusion Criteria:

  1. Suicide attempt within past 6 months or actively suicidal
  2. Severe incident of non-suicidal self-injury in past 3 months
  3. Severe episode of MDD
  4. Treatment resistant non-suicidal self-injury
  5. Frequent non-suicidal self-injury
  6. Mentally retarded
  7. Current diagnosis of: PTSD, OCD, Schizophrenia, Bipolar Disorder, Psychosis, Substance Dependence, ADHD
  8. Current substance use
  9. Currently in active treatment for same condition
  10. Currently taking antidepressant medication
  11. Medical illness likely to interfere with treatment -

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00401102

United States, New York
New York State Psychiatric Institute
New York, New York, United States, 10032
Sponsors and Collaborators
New York State Psychiatric Institute
MINT: Mental Health Initiative
Principal Investigator: Colleen Jacobson, PhD NYSPI

Responsible Party: New York State Psychiatric Institute Identifier: NCT00401102     History of Changes
Other Study ID Numbers: 5332
First Posted: November 17, 2006    Key Record Dates
Results First Posted: January 28, 2013
Last Update Posted: January 28, 2013
Last Verified: December 2012

Keywords provided by New York State Psychiatric Institute:
self-injurious behavior

Additional relevant MeSH terms:
Self-Injurious Behavior
Behavioral Symptoms