Neuropeptides in the Humane Intra- og Extracerebral Circulation.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Single Group Assignment
Masking: Single Blind
|Official Title:||Neuropeptides in the Humane Intra- og Extracerebral Circulation - in Relation to Sumatriptan in Healthy Volunteers.|
- Blood concentration of vasoactive intestinal polypeptide (VIP),
- calcitonin gene-related protein (CGRP), pituitary adenylate cyclase
- activating peptide (PACAP,) and the prostanoids
- 6-keto-PGF1α, PGE2, PGD2 and PGF2α, sampled from different
- venous catheters.
|Study Start Date:||January 2007|
|Study Completion Date:||April 2007|
|Primary Completion Date:||April 2007 (Final data collection date for primary outcome measure)|
The study is meant to give a better understanding of the basic mechanisms behind migraine, and a better understanding of the effects of sumatriptan on the trigemino vascular system.
The endpoints are changes in the plasma values of the neuropeptides vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase activating peptide (PACAP) and the prostanoids 6-keto-PGF1α, and PGE2, PGD2 og PGF2α.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00399633
|Danish Headache Center|
|Glostrup, Copenhagen, Copenhagen, Denmark, 2600|
|Principal Investigator:||Jakob Møller Hansen, MD||Danish Headache Center|