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Narrowband UVB Treatment in Patients With Vitiligo

This study has been completed.
Information provided by (Responsible Party):
Mary Sullivan-Whalen, Rockefeller University Identifier:
First received: November 10, 2006
Last updated: October 11, 2011
Last verified: October 2011

The study offers narrowband UVB light therapy to patients who have 5% of their body involved with vitiligo.

The hypothesis is that Narrowband UVB promotes melanocyte proliferation in vitiligo lesions.

Condition Intervention
Vitiligo Device: Narrowband UVB

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Effects of Narrowband UVB Phototherapy on Melanocyte Proliferation in Patients With Vitiligo

Resource links provided by NLM:

Further study details as provided by Mary Sullivan-Whalen, Rockefeller University:

Primary Outcome Measures:
  • Number of melanocytes per unit length of skin surface [ Time Frame: pre-treatment, early repigmentation, 75% repigmentation of total body ]

Secondary Outcome Measures:
  • Clinical improvement [ Time Frame: first visit and last visit ]

Enrollment: 20
Study Start Date: November 2006
Study Completion Date: November 2007
Primary Completion Date: November 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Vitiligo
adult patients (age 18 or greater) with extensive vitiligo warranting treatment with whole body NB-UVB
Device: Narrowband UVB
Treatment three to seven times weekly for a total of 12 to 26 weeks (36 to 168 treatments). Dosing of NB-UVB will begin at 100-280 mJ/cm2, depending on tolerance and skin type, and will be titrated 10-20% per session until clinical efficacy or symptomatic erythema

Detailed Description:
All patients will receive phototherapy, with narrowband UVB, three times a week for six months, or a total of 78 treatments. 6mm punch skin biopsies (2) will be done prior to starting therapy, once during treatment (2) and at the completion of the study (2). Clinical assessments and photography will be done parallel to the skin biopsies. Results (clinically and histologically) will be analyzed.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age 18 years of age or greater
  • Vitiligo with extensive skin involvement (>5% body surface affected).

Exclusion Criteria:

  • No treatment with topical steroids, calcineurin inhibitors or vitamin D analogs for at least 4 weeks prior to entering the study.
  • No treatment with systemic therapies, including methotrexate, etretinate, PUVA, or cyclosporine 4 weeks prior to entering the study.
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Please refer to this study by its identifier: NCT00398723

United States, New York
Rockefeller University Hospital
New York, New York, United States, 10021
Sponsors and Collaborators
Mary Sullivan-Whalen
Principal Investigator: James Krueger, MD Rockefeller University
  More Information

Responsible Party: Mary Sullivan-Whalen, Co-Investigator, Rockefeller University Identifier: NCT00398723     History of Changes
Other Study ID Numbers: RUH IRB # JCO 0590
Study First Received: November 10, 2006
Last Updated: October 11, 2011

Keywords provided by Mary Sullivan-Whalen, Rockefeller University:
Narrowband UBV Phototherapy
Skin biopsies

Additional relevant MeSH terms:
Pigmentation Disorders
Skin Diseases processed this record on July 26, 2017