Correction of Anaemia and Progression of Renal Failure on Transplanted Patients

Inclusion Criteria:

• Adults male or female of 18 years male or female sex to 70 years
• Patients having profited from one 1st or one the 2nd transplantation
• Patients transplanted since more than 1 year and less than 20 years.
• Patients having a CDG defined by a clearance of creatinin, lower than 50 ml/mn/1,73 m2 (according to Gault and Cockcroft) and whose renal function is stable over the last 3 months (variation of Scr of less than 20% over the last 3 months)
• Patients presenting an anaemia: Hb lower than 11.5 g/dl
• No deficiency out of iron: Saturation of the transferrin > 20% and ironnemia > 50 mg/l at the time of the screening visit
• Patients having given their written consent

Exclusion Criteria:

• Major forms of drepanocytosis or thalassaemia
• Iron Deficit (CST < 20% or ferritin < 50 mg/l)
• Haemolysis (haptoglobin < 0,30 g/l)
• Severe renal insufficiency: Clcr < 20 ml/min/1,73 m2
• Severe Hyperparathyroidy (serum PTH > 800 pg/ml)
• Evolutionary chronic inflammatory Disease (CRP > 15 mg/l)
• Acute or chronic infectious disease
• Evolutionary neoplasic Disease
• Infection by the HIV and viral cirrhosis
• Recent Antecedents of MI or AIT (< 3 months)
• Severe Arteritis of the lower limbs (Stage III or IV)
• Acute Rejection requiring a treatment in the 3 previous months
• Blood Transfusion on the last 3 months
• Evolutionary GI Ulcer on the last 3 months
• Severe Arterial HyperTension not controlled by medicamentous treatment (NOT > 170 mm Hg or PAD > 100 mm Hg under treatment)
• Epilepsy of recent diagnosis
• Relevant biological value(at screening visit) : - Proteinuria > 3 g/24h
• Serum Albumin < 30 g/l
• Platelets > 600.000/µl
• Programmed heavy surgery
• Pregnancy or breast feeding
• Administration of an experimental drug in the 30 days preceding the screening visit
• Known Over-sensitiveness to Epoetin beta
• Patients under Sirolimus
• Patients under EPO at screening visit