Evaluation of the Efficacy of Rosuvastatin in Daily Practice (TARGET)

This study has been completed.
Information provided by:
ClinicalTrials.gov Identifier:
First received: November 3, 2006
Last updated: NA
Last verified: February 2003
History: No changes posted
In this study the effect of the switch to rosuvastatin from another statin (fluvastatin, pravastatin, simvastatin, atorvastatin) was evaluated in high-risk patients with and without evident CHD and LDL-C ≥ 3.2 mmol/l. This was done in a large observational study (TARGET) representing daily practice. Primary end points analysis was the percentage of patients reaching the target of LDL-C < 3.2 mmol/l. Secondary outcomes were the changes of LDL-C, HDL-C, TC, Triglycerides (TG) and TC/HDL-C-ratio from baseline.

Condition Phase
Coronary Heart Disease
Phase 4

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Official Title: Evaluation of the Efficacy of Rosuvastatin in Daily Practice (TARGET)

Resource links provided by NLM:

Further study details as provided by AstraZeneca:

Estimated Enrollment: 3889
Study Start Date: February 2003

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • High-risk patients with and without evident CHD who had LDL-C > 3.2 mmol/l and were treated at that moment with HMG-CoA-reductase inhibitor apart from rosuvastatin.
  • Patients were aged >18 years and <70 years (men) and < 75 years (women).

Exclusion Criteria:

  • Treatment with atorvastatin 40 or 80 mg or simvastatin 80 mg
  • Patients familiar with muscular pain, myopathy or liver function disorders (inclusive elevation of serum transaminases) and/or contra-indications for treatment with rosuvastatin
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00396110

Sponsors and Collaborators
Study Chair: Ingrid van Geel, MD AstraZeneca
Study Chair: Ingeborg Vosjan, MD AstraZeneca
  More Information

ClinicalTrials.gov Identifier: NCT00396110     History of Changes
Other Study ID Numbers: 25V06  TARGET 
Study First Received: November 3, 2006
Last Updated: November 3, 2006
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by AstraZeneca:
coronary heart disease
LDL-C goal

Additional relevant MeSH terms:
Coronary Artery Disease
Coronary Disease
Heart Diseases
Myocardial Ischemia
Arterial Occlusive Diseases
Cardiovascular Diseases
Lipid Metabolism Disorders
Metabolic Diseases
Vascular Diseases
Rosuvastatin Calcium
Anticholesteremic Agents
Enzyme Inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypolipidemic Agents
Lipid Regulating Agents
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on May 23, 2016