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Polymorphisms in Inflammatory Cytokines Genes in Subjects With Obstructive Sleep Apnea

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2005 by Shaare Zedek Medical Center.
Recruitment status was:  Not yet recruiting
Information provided by:
Shaare Zedek Medical Center Identifier:
First received: November 2, 2006
Last updated: NA
Last verified: February 2005
History: No changes posted
Obstructive sleep apnea is a common sleep disorder. It is known to be related with increased body mass, abdominal obesity, insulin resistance and hypertension. It is currently believed to be a feature of the metabolic syndrome. Other features of the metabolic syndrome-such as insulin resistace were found related to inflammation and inflammatory cytokines. Several polymorphisms in the genes that encode interleukin 6,inteleukin 10 and TNF-alpha have significant influence on the amounts of cytokine production. we thus hypothesize that polymorphisms related to increased pruduction are more common in subjects with OSA than in matched controls

Sleep Apnea

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: A Cross Sectional Study of Patients With Obstructive Sleep Apnea for Polymorphisms in Genes of Inflammatory Cytokines.

Resource links provided by NLM:

Further study details as provided by Shaare Zedek Medical Center:

Estimated Enrollment: 100
Study Start Date: November 2006
Estimated Study Completion Date: November 2007
Detailed Description:
Patients attending a sleep apnea clinic for evluation will be recruited. Patients found positive for OSA will be compared to the patients with a negative study for OSA for the prevalence of polymorphisms in genes of inflammatory cytokines and cytokine levels

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients attending the sleep apnea clinic for evaluation

Exclusion Criteria:

  • patients known to have inflammatory conditions
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00395590

Contact: michal mates, MD 02-6555111 ext 55650
Contact: Gheona Altarescu

Sponsors and Collaborators
Shaare Zedek Medical Center
Study Director: mates mates, MD Ben-Gurion University of the Negev
  More Information Identifier: NCT00395590     History of Changes
Other Study ID Numbers: 5594ctil
Study First Received: November 2, 2006
Last Updated: November 2, 2006

Keywords provided by Shaare Zedek Medical Center:
OSA inflammatory cytokines, metabolic syndrome

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases processed this record on August 21, 2017