Ezetimibe Added to Statin Therapy (EASY) Study (0653-087)(COMPLETED)
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In the context of australian general practice, to determine the efficacy and safety of ezetimibe 10mg/statin 40mg coadministration in patients with uncontrolled cholesterol receiving statin 40mg or more.
Condition or disease
Drug: MK0653, ezetimibe / Duration of Treatment: 6 Weeks
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients who will remain on a stable statin dose of 40mg or more, for the duration of the study
Patients with coronary heart disease or diabetes mellitus whose cholesterol levels remain above the initial threshold for government subsidy after at least 3 months of treatment at a daily dose of 40mg or greater of a statin
Illnesses such as congestive heart failure nyha class iii or iv
Coronary bypass surgery or angioplasty with or without stent within 3 months of the enrolment visit
Unstable angina pectoris or unstable or severe peripheral vascular disease
Uncontrolled endocrine or metabolic disease known to influence serum lipids or lipoproteins, ex: type i or type ii diabetes mellitus that is poorly controlled
Serum creatinine >0.18mmol/l at enrolment or active renal disease with significant proteinuria
Disorders of the haematologic, digestive (including malabsorptive disorders)
Central nervous system including cerebrovascular disease and degenerative diseases that would limit study evaluation or participation
Active acute or chronic hepatobiliary disease
Patients taking the following medication: medications known to interact with statin medication including antifungal azoles, macrolide antibiotics, telithromycin; nefazodone; protease inhibitors; amiodarone; danazol and verapamil; fibrates; cyclosporin