Efficacy and Feasibility of an Intermittent Weight Loss Program.
The goal of the study is to measure the effect of an approach including phases of active weight loss broken by weight stabilisation periods (named intermittent weight loss) on the metabolic profile.
First, the intermittent weight loss approach will contribute to create an artificial transitory steady state during the weight loss treatment that will help to minimize the adverse effects of the standard approach on muscle mass and resting metabolic rate. Second, despite a comparable fat mass loss, the intermittent weight loss approach will improve the metabolic profile to a greater degree compared to the standard approach. Finally, the intermittent weight loss approach will be associated with less weight regain after the treatment since the beneficial effect on muscle mass and metabolic rate.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Efficacy and Feasibility of an Intermittent Weight Loss Program: A Pilot Study.|
- Body composition (fat mass and lean body mass): after 0, 5, 10, 15, 20 and 25 weeks, as well as 12-month post-intervention
- Fasting lipids: baseline, 5, 10, 15, 20 and 25 weeks, as well as 12-month post-intervention
- Resting metabolic rate: baseline, 5, 10, 15, 20 and 25 weeks, as well as 12-month post-intervention
- Resting blood pressure: baseline, 5, 10, 15, 20 and 25 weeks, as well as 12-month post-intervention
- OGTT: baseline and 25 weeks
- Dietary habits: baseline,25 weeks and 12-month post-intervention
|Study Start Date:||September 2005|
|Estimated Study Completion Date:||June 2007|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00395356
|Institut universitaire de gériatrie de Sherbrooke|
|Sherbrooke, Quebec, Canada, J1H 4C4|
|Principal Investigator:||Martin Brochu, PhD||Université de Sherbrooke|