Improving Metabolism With HDL Cholesterol

This study has been completed.
Baker Heart Research Institute
Information provided by:
Bayside Health Identifier:
First received: October 31, 2006
Last updated: May 9, 2011
Last verified: October 2006

High levels of good cholesterol (HDL) in our blood decreases our chance of having a heart attack. This relates in part to the role good cholesterol plays in reducing build up of fat in the arteries. However, good cholesterol has many other protective effects. We have recently identified three enzymes (proteins) activated by HDL in cells lining the blood vessels, which may be responsible for some of HDL's protective actions.

Condition Intervention
Heart Disease
Drug: rHDL

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: A Novel Mechanism Mediating Anti-atherosclerotic and Metabolic Actions of HDL Cholesterol

Resource links provided by NLM:

Further study details as provided by Bayside Health:

Primary Outcome Measures:
  • Metabolic parameters

Enrollment: 13
Study Start Date: March 2006
Study Completion Date: March 2008
Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Aged 18 - 65 years
  • Free of overt coronary disease
  • Body mass index <35 kg.m-2
  • Fasting plasma glucose > 7 mmol/L-1
  • No major illness

Exclusion Criteria:

  • Unable to give informed consent
  • Smokers
  • Abnormal LFT, U&E, FBE or creatinine
  Contacts and Locations
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Please refer to this study by its identifier: NCT00395148

Australia, Victoria
Alfred Hospital
Melbourne, Victoria, Australia, 3004
Sponsors and Collaborators
Bayside Health
Baker Heart Research Institute
Principal Investigator: Bronwyn A Kingwell, PhD Baker Heart Research Institute
  More Information


Responsible Party: Prof Bronwyn Kingwell, Baker IDI Heart & Diabetes Institute Identifier: NCT00395148     History of Changes
Other Study ID Numbers: 175/04
Study First Received: October 31, 2006
Last Updated: May 9, 2011
Health Authority: Australia: Therapeutic Goods Administration processed this record on October 06, 2015