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Changes in Cerebrovascular Reactivity During Cognitive Activation After Cardiopulmonary Bypass: Relation With Intraoperative Embolic Load and Postoperative Neuropsychological Dysfunctions

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ClinicalTrials.gov Identifier: NCT00394108
Recruitment Status : Completed
First Posted : October 31, 2006
Last Update Posted : December 28, 2007
Sponsor:
Collaborator:
Information provided by:

Study Description
Brief Summary:
The study aims to evaluate neuropsychological disorders in CABG patients. Measurements are performed 1 day before, 6 days, 6 months and 3-5 years after the surgery. The relation with cerebrovascular reactivity and embolic load (measured by transcranial Doppler Ultrasonography) is evaluated. Two surgery techniques (on- and off-pump CABG) are compared.

Condition or disease Intervention/treatment
CABG-Patients Procedure: Determination of neuropsychological status

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 66 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Changes in Cerebrovascular Reactivity During Cognitive Activation After Cardiopulmonary Bypass: Relation With Intraoperative Embolic Load and Postoperative Neuropsychological Dysfunctions
Study Start Date : August 1999
Study Completion Date : July 2002
Arms and Interventions


Outcome Measures

Primary Outcome Measures :
  1. Neuropsychological status [ Time Frame: after 6 days, 6 months and 3-5 years ]

Secondary Outcome Measures :
  1. Relation with intra-operative embolic load

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 69 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • CABG-patients (not urgent)
  • < 70 years old
  • Righthanded

Exclusion Criteria:

  • Neurological or psychiatric disease
  • Psychoactive medication
  • Valve operation
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00394108


Locations
Belgium
University Hospital Ghent
Ghent, Belgium, 9000
Sponsors and Collaborators
University Ghent
Fund for Scientific Research, Flanders, Belgium
Investigators
Principal Investigator: Guy Vingerhoets, Psychologist University Hospital, Ghent
More Information

Additional Information:
ClinicalTrials.gov Identifier: NCT00394108     History of Changes
Other Study ID Numbers: 1997/098
First Posted: October 31, 2006    Key Record Dates
Last Update Posted: December 28, 2007
Last Verified: December 2007