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Changes in Cerebrovascular Reactivity During Cognitive Activation After Cardiopulmonary Bypass: Relation With Intraoperative Embolic Load and Postoperative Neuropsychological Dysfunctions

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00394108
First Posted: October 31, 2006
Last Update Posted: December 28, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Fund for Scientific Research, Flanders, Belgium
Information provided by:
University Ghent
  Purpose
The study aims to evaluate neuropsychological disorders in CABG patients. Measurements are performed 1 day before, 6 days, 6 months and 3-5 years after the surgery. The relation with cerebrovascular reactivity and embolic load (measured by transcranial Doppler Ultrasonography) is evaluated. Two surgery techniques (on- and off-pump CABG) are compared.

Condition Intervention
CABG-Patients Procedure: Determination of neuropsychological status

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Changes in Cerebrovascular Reactivity During Cognitive Activation After Cardiopulmonary Bypass: Relation With Intraoperative Embolic Load and Postoperative Neuropsychological Dysfunctions

Further study details as provided by University Ghent:

Primary Outcome Measures:
  • Neuropsychological status [ Time Frame: after 6 days, 6 months and 3-5 years ]

Secondary Outcome Measures:
  • Relation with intra-operative embolic load

Enrollment: 66
Study Start Date: August 1999
Study Completion Date: July 2002
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 69 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • CABG-patients (not urgent)
  • < 70 years old
  • Righthanded

Exclusion Criteria:

  • Neurological or psychiatric disease
  • Psychoactive medication
  • Valve operation
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00394108


Locations
Belgium
University Hospital Ghent
Ghent, Belgium, 9000
Sponsors and Collaborators
University Ghent
Fund for Scientific Research, Flanders, Belgium
Investigators
Principal Investigator: Guy Vingerhoets, Psychologist University Hospital, Ghent
  More Information

Additional Information:
ClinicalTrials.gov Identifier: NCT00394108     History of Changes
Other Study ID Numbers: 1997/098
First Submitted: October 30, 2006
First Posted: October 31, 2006
Last Update Posted: December 28, 2007
Last Verified: December 2007