A Study to Compare Two Different Brain Imaging Techniques in Healthy Volunteers and in Schizophrenic Patients
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A direct comparison of Positron Emission Tomography (PET) (11C-Raclopride) and Single Photon Emission Computed Tomography (SPECT) (123I-IBZM) D2 RO measurements would allow GSK to gain understanding on the SPECT results obtained with SB773812, and to accurately interpret future D2 RO results from either PET or SPECT studies with new compounds.
An Open-label, Cross-over Study, to Compare the PET and SPECT Measurement of Antipsychotic-induced D2 Receptor Occupancy, in a Group of Healthy Volunteers and in Another Group of Patients With Schizophrenia and Other Psychotic Disorders
Study Start Date
Actual Primary Completion Date
Actual Study Completion Date
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
This is a methodology study.
Not pregnant or becoming pregnant during the study.
No abnormality in clinical examination, clinical laboratory test or ECG.
Not taking drugs
Patients with schizophrenia, schizophreniform disorder or schizoaffective disorders.
Patients with at least 1 month antipsychotic monotherapy with either risperidone, olanzapine or clozapine.
Healthy volunteers with no neurological or psychiatric illness.
Have received other antipsychotic during the last month or neuroleptics during the last year.
If you have taken part in investigations you should not receive a radiation dose of more than 10 mSv over any 3 year period.
History of bleeding disorder or are taking medication that affects blood clotting
History of substance dependence (except nicotine)
Gross head deformity.
Unable to lie still in the PET or SPECT camera for 1 hour and a half.
The presence of a cardiac pacemaker or other electronic device or ferromagnetic metal foreign bodies.