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White Matter in Pediatric Bipolar Disorder: A DTI Study

This study has been completed.
American Academy of Child Adolescent Psychiatry.
Eli Lilly and Company
Information provided by:
Cambridge Health Alliance Identifier:
First received: October 19, 2006
Last updated: December 2, 2010
Last verified: December 2010
Fourteen subjects with bipolar disorder and 14 matching healthy controls, aged 6-13, will receive a magnetic resonance imaging (MRI) scan on a 3 Tesla scanner. They will also have a clinical interview, including the KSADS-PL. All subjects must be right-handed.

Bipolar Disorder

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: White Matter Connectivity in Pediatric Bipolar Disorder: A Diffusion Tensor Imaging Study

Resource links provided by NLM:

Further study details as provided by Cambridge Health Alliance:

Primary Outcome Measures:
  • Fractional anisotropy in brain white matter [ Time Frame: Baseline ]

Estimated Enrollment: 28
Study Start Date: September 2005
Study Completion Date: October 2008
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Children with bipolar disorder
Healthy comparison children

Detailed Description:
We propose to investigate the connectivity of white matter tracts using diffusion tensor imaging (DTI) in children with very early onset bipolar disorder (BPD). We hypothesize that the connectivity between the prefrontal cortex and the temporal lobe and parietal lobe and limbic structures will be abnormal, indicating white matter and gray matter deficits in early onset BPD. We also hypothesize that the superior lateral fasciculus cingulum bundle and the inferior lateral fasciculus will have decreased fractional anisotropy in very early onset BPD relative to healthy controls.

Ages Eligible for Study:   6 Years to 13 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Bipolar Disorder

Inclusion Criteria:

  • Age 6 to 13
  • Male or female
  • Right-handed

Exclusion Criteria:

  • IQ less than 70
  • Learning disabilities
  • History of autism, schizophrenia, anorexia or bulimia nervosa
  • Substance abuse
  • Claustrophobia
  • Metal in body
  • Pregnancy or lactation
  Contacts and Locations
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Please refer to this study by its identifier: NCT00391235

United States, Massachusetts
Cambridge Health Alliance
Medford, Massachusetts, United States, 02155
Sponsors and Collaborators
Cambridge Health Alliance
American Academy of Child Adolescent Psychiatry.
Eli Lilly and Company
Principal Investigator: Jean A Frazier, MD Cambridge Health Alliance
  More Information

Responsible Party: Jean Frazier, MD, Cambridge Health Alliance Identifier: NCT00391235     History of Changes
Other Study ID Numbers: CHA-IRB-0132/09/05
Study First Received: October 19, 2006
Last Updated: December 2, 2010

Keywords provided by Cambridge Health Alliance:
bipolar disorder
magnetic resonance imaging
white matter
diffusion tensor imaging

Additional relevant MeSH terms:
Bipolar Disorder
Pathologic Processes
Bipolar and Related Disorders
Mental Disorders processed this record on September 20, 2017