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Avastin for CNV Secondary to Pattern Dystrophy

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2006 by University of Trieste.
Recruitment status was:  Recruiting
Information provided by:
University of Trieste Identifier:
First received: October 20, 2006
Last updated: NA
Last verified: October 2006
History: No changes posted

The natural history of subfoveal CNV secondary to Pattern Dystrophy is little understood, but it seems that visual function may be preserved only in the short-term follow-up, with progressive deterioration thereafter.

Photodynamic therapy with verteporfin is the most studied therapeuthic option for this kindf of lesion, but unfortunately, this approach does not appear to guarantee long-term vision stabilization, and alternative therapies should be investigated.

Condition Intervention Phase
Choroidal Neovascularization Secondary to Pattern Dystrophy
Procedure: intravitreal triamcinolone injection of avastin (1.25 mg)
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind
Primary Purpose: Treatment
Official Title: Intravitreal Avastin Injection for the Treatment of Choroidal Neovascularization Secondary to Pattern Dystrophy

Resource links provided by NLM:

Further study details as provided by University of Trieste:

Primary Outcome Measures:
  • number of eyes with <15 letter loss (approximately <3 lines) at 6-month examination compared with the baseline value
  • numeber of eyes with <15 letter loss at 12-month examinations, compared with the baseline value.

Secondary Outcome Measures:
  • CNV progression
  • number of injections.

Estimated Enrollment: 5
Study Start Date: July 2006
Estimated Study Completion Date: October 2006
Detailed Description:

Diagnosis of Pattern Dystrophy Diagnosis of subfoveal CNV Intravitreal injection of avastin (1.25 mg) in operating room under sterile condition.

Retreatment on the basis of the detection of disease progression and of lack of central retinal thickness reduction on OCT.


Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • diagnosis of RPD (hyperpigmented yellowish-greyish network, other family members sharing RPD, normal electroretinogram and normal/subnormal electrooculogram)
  • classic or occult CNV involving the foveal avascular zone’s geometric centre

Exclusion Criteria:

  • conditions other than RPD
  • intraocular surgery or capsulotomy within the last 2 or 1 months
  • pregnancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT00391144

Contact: Maurizio B Parodi, MD +39 040 772449
Contact: Giuseppe Ravalico, MD +39 040 772449

Clinica Oculistica, Azienda Ospedaliero-Universitaria di Trieste Recruiting
Trieste, TS, Italy, 34129
Contact: Giuseppe Ravalico, MD    +39 040 772449   
Sponsors and Collaborators
University of Trieste
Principal Investigator: Maurizio B Parodi, MD Clinica Oculistica, Azienda Ospedaliero-Universitaria di Trieste
Principal Investigator: Pierluigi Iacono, MD Clinica Oculistica, Azienda Ospedaliero-Universitaria di Trieste
Study Director: Giuseppe Ravalico, MD Clinica Oculistica, Azienda Ospedaliero-Universitaria di Trieste
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00391144     History of Changes
Other Study ID Numbers: 1/2006
Study First Received: October 20, 2006
Last Updated: October 20, 2006

Keywords provided by University of Trieste:
Pattern Dystrophy
Choroidal Neovascularization
Intravitreal Avastin Injection

Additional relevant MeSH terms:
Neoplasm Metastasis
Neovascularization, Pathologic
Choroidal Neovascularization
Neoplastic Processes
Pathologic Processes
Choroid Diseases
Uveal Diseases
Eye Diseases
Triamcinolone hexacetonide
Triamcinolone Acetonide
Triamcinolone diacetate
Anti-Inflammatory Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Immunosuppressive Agents
Immunologic Factors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Growth Inhibitors
Antineoplastic Agents processed this record on May 24, 2017