The "COSMOS"-Study (Copeptin in Osmoregulation and Stress Assessment)
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|ClinicalTrials.gov Identifier: NCT00390962|
Recruitment Status : Completed
First Posted : October 23, 2006
Last Update Posted : September 23, 2008
Sodium imbalance is common and an adverse prognostic factor in hospitalized patients. However, identifying the causes of sodium imbalance is challenging in clinical practice. Levels of antidiuretic hormone (ADH) are elevated in patients with stroke correlating with disease severity and stress level; however, its measurement is cumbersome. ADH is derived from a larger precursor peptide along with Copeptin, which is a more stable peptide directly mirroring the production of ADH. Copeptin can be assayed readily in plasma. Early prognostic factors to predict in-hospital mortality and medium/long-term outcome in critically ill neurological patients, are helpful to guide and tailor early decisions on treatment, discharge from the intensive care unit and application of interventions to prevent deterioration of neurological functions.
We hypothesize that copeptin will improve the diagnostic accuracy to diagnose sodium imbalances as compared to routinely used markers Furthermore, we hypothesize that Copeptin will be a reliable prognostic tool, dependent or independent of sodium imbalance, to predict short-term (i.e. in-hospital) and medium-term (i.e. 3 months) clinical outcome in stroke patients.
|Condition or disease|
|Stroke Transient Ischemic Attack|
Show Detailed Description
|Study Type :||Observational|
|Actual Enrollment :||469 participants|
|Official Title:||Copeptin as a Novel Diagnostic and Prognostic Marker in the Management of Neurological and Neurosurgical Patients With Sodium Imbalance The "COSMOS"-Study (Copeptin in Osmoregulation and Stress Assessment)|
|Study Start Date :||November 2006|
|Actual Primary Completion Date :||March 2008|
|Actual Study Completion Date :||March 2008|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00390962
|University Hospital Basel|
|Basel, BS, Switzerland, 4051|
|Study Chair:||Beat Mueller, Prof||University Hospital, Basel, Switzerland|