This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Modification of Posttetanic Count (PTC) for Monitoring Deep Neuromuscular Block II

This study has been completed.
Information provided by:
Rigshospitalet, Denmark Identifier:
First received: October 19, 2006
Last updated: September 2, 2010
Last verified: September 2010
The purpose of this study is to examine the relationship between post-tetanic count (PTC) and time to first response to Train of four (TOF) stimulation during deep neuromuscular blockade induced by rocuronium.

Condition Intervention Phase
Neuromuscular Blockade Procedure: Post-tetanic count frequency Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment

Further study details as provided by Rigshospitalet, Denmark:

Primary Outcome Measures:
  • Time to first response to TOF stimulation (T1)

Secondary Outcome Measures:
  • Time to second response to TOF stimulation (T2)
  • Time to first post-tetanic count (PTC)
  • Number of post-tetanic count at first response to TOF
  • Time to T1=25%
  • Interval 25-75%
  • Time to TOF 0.9
  • Time to TOF 1.0

Enrollment: 45
Study Start Date: October 2006
Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • ASA 1-3
  • General anaesthesia >1 hour
  • Surgery in supine position with possibility of monitoring the neuromuscular blockade at the thumb (n.ulnaris stimulation).
  • Written informed content

Exclusion Criteria:

  • Neuromuscular disorders, hepatic and renal dysfunction
  • Medication expected to interfere with the neuromuscular blocking agent
  • Allergy to any medication used during anaesthesia
  • Body weight less or exceeding 20% of the ideal body weight
  • Pregnancy or breastfeeding
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00390507

Dep. of Anesthesia, Rigshospitalet
Copenhagen, Denmark, 2100
Dep. of Anesthesia, Herlev hospital
Herlev, Denmark, 2730
Sponsors and Collaborators
Rigshospitalet, Denmark
Principal Investigator: Casper C Kjaer, MD Rigshospitalet, Denmark
  More Information Identifier: NCT00390507     History of Changes
Other Study ID Numbers: PTC-II
Study First Received: October 19, 2006
Last Updated: September 2, 2010

Keywords provided by Rigshospitalet, Denmark:
Posttetanic count
Train of four
Neuromuscular blockade processed this record on September 21, 2017