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Genetic Studies in Interstitial Cystitis (IC)

This study is currently recruiting participants.
See Contacts and Locations
Verified July 2017 by Louis Kunkel, Boston Children's Hospital
Sponsor:
Information provided by (Responsible Party):
Louis Kunkel, Boston Children's Hospital
ClinicalTrials.gov Identifier:
NCT00389142
First received: October 17, 2006
Last updated: July 28, 2017
Last verified: July 2017
  Purpose

Interstitial cystitis (IC), also called painful bladder syndrome (PBS), or chronic pelvic pain syndrome(CPPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another.

In this study, we are collecting genetic material and medical information from families in North America in an attempt to identify genetic factors that may cause IC/PBS/CPPS. We are enrolling families and individuals with IC/PBS/CPPS and their family members (both family members with and without IC like symptoms).


Condition
Interstitial Cystitis Painful Bladder Syndrome Chronic Pelvic Pain Syndrome

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Genetic Studies in Interstitial Cystitis/Painful Bladder Syndrome/Chronic Pelvic Pain Syndrome (IC/PBS/CPPS)

Resource links provided by NLM:


Further study details as provided by Louis Kunkel, Boston Children's Hospital:

Biospecimen Retention:   Samples With DNA
We will collect and store DNA (via saliva) and urine on all participants.

Estimated Enrollment: 500
Actual Study Start Date: January 15, 2006
Estimated Study Completion Date: December 31, 2021
Estimated Primary Completion Date: December 31, 2020 (Final data collection date for primary outcome measure)
Detailed Description:
To fully describe the phenotype of interstitial cystitis (IC)/painful bladder syndrome (PBS)/chronic pelvic pain syndrome (CPPS), in adults and children, and to correlate the phenotypic information to the genotypic findings utilizing linkage analysis, whole exome sequencing and candidate gene studies. Both individuals and families with IC/PBS/CPPS symptoms will be recruited to give a DNA (from saliva) and urine samples and answer 2 questionnaires. Travel to Boston NOT necessary.
  Eligibility

Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We are collecting patients throughout North America (including the United States and Canada)
Criteria

Inclusion Criteria:

  • Males and females of any age
  • Urinary frequency - more than 1X/hour, and/or
  • Dysuria, and/or
  • Pelvic, suprapubic, or abdominal pain - for 3 months or longer
  • Nocturia
  • Normal urinary stream (by history)
  • No evidence of active bacterial UTI (no pyuria & negative urinary culture for last 3 months)
  • First degree relative of someone with above symptoms

Exclusion Criteria:

  • Major structural/anatomical urinary tract abnormalities by ultrasound
  • Underlying inborn conditions affecting the urinary tract
  • Surgery/chemotherapy affected pelvic area
  • GI or GU cancers
  • Severe Constipation in children only
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00389142

Contacts
Contact: Elicia A Estrella, MS, LCGC 617-919-4552 elicia.estrella@childrens.harvard.edu
Contact: Stephanie J Brewster, MS, LCGC 617-919-4551 stephanie.brewster@childrens.harvard.edu

Locations
United States, Massachusetts
Children's Hospital Recruiting
Boston, Massachusetts, United States, 02115
Contact: Elicia A Estrella, MS, LCGC    617-919-4552    elicia.estrella@childrens.harvard.edu   
Contact: Stephanie J Brewster, MS, LCGC    617-919-4551    stephanie.brewster@childrens.harvard.edu   
Sponsors and Collaborators
Boston Children’s Hospital
Investigators
Principal Investigator: Louis M Kunkel, Ph.D. Children's Hosptial, Boston
  More Information

Additional Information:
Publications:
Responsible Party: Louis Kunkel, Professor of Genetics and Pediatrics, Harvard Medical School, Boston Children's Hospital
ClinicalTrials.gov Identifier: NCT00389142     History of Changes
Other Study ID Numbers: 04-11-160
91208 ( Other Grant/Funding Number: Broad Institute )
Study First Received: October 17, 2006
Last Updated: July 28, 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description: Data from individual participants will be shared with other researcher, but participant information will be de-identified.

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Louis Kunkel, Boston Children's Hospital:
pelvic pain
urinary frequency
painful bladder
urinary urgency

Additional relevant MeSH terms:
Pelvic Pain
Syndrome
Pain
Cystitis
Cystitis, Interstitial
Disease
Pathologic Processes
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Urinary Bladder Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on August 16, 2017