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Radiation Induced Atherosclerosis in Breast Cancer Patients

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2005 by Hadassah Medical Organization.
Recruitment status was:  Recruiting
Information provided by:
Hadassah Medical Organization Identifier:
First received: October 15, 2006
Last updated: May 15, 2007
Last verified: December 2005
Radiation induced accelerated atherosclerosis is a well known entity that occurs in different regions, according to the therapy delivered.It is usually begins to be clinically evident several years after the radiation incident, as there is sufficient functional reserve to these vessels.Our proposal is aimed to better characterize this side effect. For that purpose, we have chosen to study women who received radiation to the breast, in which part of the carotid in the irradiated side was in the high energy radiation field. We will use Intima Media Thickening ultrasound to study the pattern of atherosclerosis plaque formation in radiated carotid arteries as compared to non-irradiated carotid arteries in women who are receiving radiation therapy for breast cancer.

Condition Intervention
Abnormalities, Radiation-Induced
Breast Cancer
Procedure: carotid intima-media thickening ultrasound

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Radiation Induced Atherosclerosis in Breast Cancer Patients

Resource links provided by NLM:

Further study details as provided by Hadassah Medical Organization:

Estimated Enrollment: 350
Study Start Date: October 2006
Estimated Study Completion Date: January 2010
  Show Detailed Description


Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • women 18-85 Y.O.
  • received or about to receive unilateral breast and supraclavicular radiation therapy
  • No evidence of disease

Exclusion Criteria:

  • prisoners
  Contacts and Locations
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Please refer to this study by its identifier: NCT00388713

Contact: Arik Tzukert, DMD 00 972 2 6776095
Contact: Hadas Lemberg, PhD 00 972 2 6777572

Hadassah Medical Organization Recruiting
Jerusalem, Israel, 91120
Contact: Arik Tzukert, DMD    00 972 2 6776095   
Contact: Hadas Lemberg, PhD    00 972 2 6777572   
Principal Investigator: Amichay Meirovitz, MD         
Sponsors and Collaborators
Hadassah Medical Organization
Principal Investigator: Amichay Meirovitz, MD Hadassah University Hospital, Jerusalem, Israel
  More Information

Publications: Identifier: NCT00388713     History of Changes
Other Study ID Numbers: ASBCO5- HMO-CTIL
Study First Received: October 15, 2006
Last Updated: May 15, 2007

Keywords provided by Hadassah Medical Organization:
Radiation therapy
Radiation-Induced Atherosclerosis
Carotid Artery Diseases
Breast Cancer
Intima Media thickening Ultrasound

Additional relevant MeSH terms:
Breast Neoplasms
Abnormalities, Radiation-Induced
Neoplasms by Site
Breast Diseases
Skin Diseases
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Congenital Abnormalities
Radiation Injuries
Wounds and Injuries processed this record on May 25, 2017