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Family Atherosclerosis Counseling and Testing Project

This study has been completed.
Information provided by:
University of British Columbia Identifier:
First received: October 11, 2006
Last updated: August 6, 2008
Last verified: August 2008
Family history of early atherosclerotic disease in a first-degree relative [(FDR) sibling, parent or child] is an important risk factor for coronary artery and/or vascular disease. The risk increases ~ 2 - 7 times over that of general population. Increased thickness of the intima and media of carotid arterial wall, increased rate of plaque formation is an independent predictor of cardiovascular disease. Also it is shown that increased level of calcium deposition in the arterial wall is also associated with increased level of coronary artery narrowing. We will assess the occurrence and severity of abnormalities of intima media thickness (IMT) and/or plaque formation and increased calcium deposition in the coronary arteries and their relation to the well known traditional risk factors (plasma glucose, smoking, BMI, waist circumference, blood pressure, total cholesterol, low density lipoprotein, total cholesterol/high density lipoprotein ratio) and non-traditional risk factors (C-reactive protein, Lpa, homocysteine) in FDRs of index patients with early onset of heart or vascular disease and appropriate control population. Also to determine which of the above factor can assess IMT and Ca score better. This may help to reduce the cost of investigation, and to identify the population at high risk of developing cardiovascular disease, which may help the physicians to treat early on before cardiovascular complications occur. Also this may help to reduce the cost of invasive tests, hospital admissions and medical costs overall by reducing the morbidity and mortality.

Condition Phase
Coronary Artery Disease
Phase 1
Phase 2

Study Type: Observational
Official Title: Family Atherosclerosis Counseling and Testing Project (FACT)

Resource links provided by NLM:

Further study details as provided by University of British Columbia:

Study Start Date: February 2003
Study Completion Date: October 2006
Primary Completion Date: October 2006 (Final data collection date for primary outcome measure)
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Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • First degree relatives of patients with early onset of cardiovascular disease (men<50 and women<60 years of age).
  Contacts and Locations
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Please refer to this study by its identifier: NCT00387595

Sponsors and Collaborators
University of British Columbia
Principal Investigator: Jiri Frohlich University of British Columbia
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Dr. Jiri Frohlich, University of British Columbia Identifier: NCT00387595     History of Changes
Other Study ID Numbers: P02-0103
Study First Received: October 11, 2006
Last Updated: August 6, 2008

Keywords provided by University of British Columbia:
Family History
CV Risk Factors

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases processed this record on May 25, 2017