Exercise and Cardiovascular Control During Upright Tilt in Older Adults With Type 2 Diabetes
|Cardiovascular Diabetic||Behavioral: Aerobic Exercise and Strength Exercise Behavioral: Strength training|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Other
|Official Title:||Exercise and Cardiovascular Control During Upright Tilt in Older Adults With Type 2 Diabetes|
- Pulse wave velocity (central and peripheral) [ Time Frame: Unspecified ]
- Drop in middle cerebral artery velocity with upright tilting [ Time Frame: Unspecified ]
- Drop in blood pressure with upright tilt [ Time Frame: Unspecified ]
- Arterial baroreflex sensitivity [ Time Frame: Unspecified ]
- Time and frequency domain measures of heart rate variability [ Time Frame: Unspecified ]
- Fasting blood glucose, HgbA1C [ Time Frame: Unspecified ]
- VO2max [ Time Frame: Unspecified ]
- Dynamometry measures of muscle strength [ Time Frame: Unspecified ]
- Resting and maximal heart rate [ Time Frame: Unspecified ]
- Waist to hip ratio, BMI [ Time Frame: Unspecified ]
- Lean body mass/% fat [ Time Frame: Unspecified ]
- Catecholamines [ Time Frame: Unspecified ]
- Increase in Gosling's pulsatility index [ Time Frame: Unspecified ]
- Linear transfer-function analysis of cerebral autoregulation during upright tilt [ Time Frame: Unspecified ]
|Actual Study Start Date:||February 2006|
|Study Completion Date:||April 2012|
|Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
|Active Comparator: 1||
Behavioral: Aerobic Exercise and Strength Exercise
6 months of aerobic training exercise. regulated by heart rate; work up to 80% of maximal heart rate on treadmill or stationary bike; 3 hours a week, 90% attendance.
|Active Comparator: 2||
Behavioral: Strength training
6 months of strength training exercise using weight machines involving legs and arms: 12-15 repetitions of weights per exercise; 3 hours a week, 90% attendance.
No Intervention: 3
No intervention, only testing during 6 months.
- PURPOSE: Older adults with diabetes faint frequently, due to an impairment in the cardiovascular control mechanisms (arterial baroreceptor function, autonomic nervous system function and cerebral autoregulation) that prevent syncope. The purpose of this study is to examine the ability of different intensities of aerobic exercise to reverse these impairments.
HYPOTHESES: a) Aerobic or strength training will improve the compensatory cardiovascular responses that prevent syncope in older adults with Type 2 diabetes. Aerobic training will:
- increase arterial baroreflex sensitivity
- increase heart rate variability (marker of autonomic nervous system function)
- decrease cerebrovascular resistance
improve cerebral autoregulation during upright tilt. b) There will be relationship between the improvement in compensatory cardiovascular responses and aerobic or strength training.
c) The majority of the benefits of aerobic or strength exercise on the above parameters will with which training, allowing for the design of more practicable training prescriptions than that used in a research setting.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00387452
|Canada, British Columbia|
|Vancouver General Hospital Research Pavilion|
|Vancouver, British Columbia, Canada, V5Z 1L8|
|Principal Investigator:||Kenneth Madden, MD||University of British Columbia|