Exercise and Cardiovascular Control During Upright Tilt in Older Adults With Type 2 Diabetes
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|ClinicalTrials.gov Identifier: NCT00387452|
Recruitment Status : Completed
First Posted : October 13, 2006
Last Update Posted : April 14, 2017
|Condition or disease||Intervention/treatment||Phase|
|Cardiovascular Diabetic||Behavioral: Aerobic Exercise and Strength Exercise Behavioral: Strength training||Not Applicable|
- PURPOSE: Older adults with diabetes faint frequently, due to an impairment in the cardiovascular control mechanisms (arterial baroreceptor function, autonomic nervous system function and cerebral autoregulation) that prevent syncope. The purpose of this study is to examine the ability of different intensities of aerobic exercise to reverse these impairments.
HYPOTHESES: a) Aerobic or strength training will improve the compensatory cardiovascular responses that prevent syncope in older adults with Type 2 diabetes. Aerobic training will:
- increase arterial baroreflex sensitivity
- increase heart rate variability (marker of autonomic nervous system function)
- decrease cerebrovascular resistance
improve cerebral autoregulation during upright tilt. b) There will be relationship between the improvement in compensatory cardiovascular responses and aerobic or strength training.
c) The majority of the benefits of aerobic or strength exercise on the above parameters will with which training, allowing for the design of more practicable training prescriptions than that used in a research setting.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||64 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Exercise and Cardiovascular Control During Upright Tilt in Older Adults With Type 2 Diabetes|
|Actual Study Start Date :||February 2006|
|Actual Primary Completion Date :||April 2012|
|Actual Study Completion Date :||April 2012|
|Active Comparator: 1||
Behavioral: Aerobic Exercise and Strength Exercise
6 months of aerobic training exercise. regulated by heart rate; work up to 80% of maximal heart rate on treadmill or stationary bike; 3 hours a week, 90% attendance.
|Active Comparator: 2||
Behavioral: Strength training
6 months of strength training exercise using weight machines involving legs and arms: 12-15 repetitions of weights per exercise; 3 hours a week, 90% attendance.
No Intervention: 3
No intervention, only testing during 6 months.
- Pulse wave velocity (central and peripheral)
- Drop in middle cerebral artery velocity with upright tilting
- Drop in blood pressure with upright tilt
- Arterial baroreflex sensitivity
- Time and frequency domain measures of heart rate variability
- Fasting blood glucose, HgbA1C
- Dynamometry measures of muscle strength
- Resting and maximal heart rate
- Waist to hip ratio, BMI
- Lean body mass/% fat
- Increase in Gosling's pulsatility index
- Linear transfer-function analysis of cerebral autoregulation during upright tilt
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00387452
|Canada, British Columbia|
|Vancouver General Hospital Research Pavilion|
|Vancouver, British Columbia, Canada, V5Z 1L8|
|Principal Investigator:||Kenneth Madden, MD||University of British Columbia|