Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Effect Of Rilapladib (SB-659032) On Platelet Aggregation

This study has been completed.
Information provided by (Responsible Party):
GlaxoSmithKline Identifier:
First received: October 10, 2006
Last updated: April 14, 2015
Last verified: April 2015
The purpose of this study is to compare the effects of repeat doses of SB-659032 with placebo on platelet aggregation in subjects.

Condition Intervention Phase
Healthy Subjects
Drug: Rilapladib (SB-659032)
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Diagnostic
Official Title: A Double Blind, Placebo Controlled, Parallel Study to Evaluate Effects of Repeat Doses of Rilapladib on Platelet Aggregation in Healthy Male Volunteers

Further study details as provided by GlaxoSmithKline:

Primary Outcome Measures:
  • Collagen EC50 values on Day 35 (or 21 days post last dose) as determine by optical aggregometry. [ Time Frame: on Day 35 (or 21 days post last dose) as determine by optical aggregometry ]

Secondary Outcome Measures:
  • Collagen EC50 values on Day 1 and Day 14 as determined by optical aggregometry Plasma Lp-PLA2 activity Clinical safety data Concentrations of rilapladib and SB-664601. [ Time Frame: on Day 1 and Day 14 as determined by optical aggregometry ]

Enrollment: 58
Study Start Date: October 2006
Study Completion Date: April 2007
Primary Completion Date: April 2007 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Subjects with QTc < 450 msec as measured at screening.

Exclusion Criteria:

  • History of asthma.
  • Smokers.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00387257

Australia, New South Wales
GSK Investigational Site
Randwick, New South Wales, Australia, 2031
Sponsors and Collaborators
Study Director: GSK Clinical Trials GlaxoSmithKline
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: GlaxoSmithKline Identifier: NCT00387257     History of Changes
Other Study ID Numbers: LP2108364
Study First Received: October 10, 2006
Last Updated: April 14, 2015

Keywords provided by GlaxoSmithKline:
platelet aggregation

Additional relevant MeSH terms:
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases processed this record on May 25, 2017