Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment
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|ClinicalTrials.gov Identifier: NCT00387062|
Recruitment Status : Completed
First Posted : October 12, 2006
Last Update Posted : June 24, 2008
|Condition or disease||Intervention/treatment||Phase|
|Breast Cancer Cognitive Symptoms Memory Disorders||Device: Computer-based Cognitive Training||Phase 1|
Breast cancer is the most common malignancy in women in the United States, with an estimated 211,240 new cases of invasive breast cancer diagnosed among women, and 1,700 diagnosed in men, in 2005. While cure rates have improved significantly, chemotherapy for breast cancer is associated with a number of negative side effects. One of which is a deficit in cognitive function, a condition commonly referred to as "chemobrain". While the debate about cognitive decline being a result of chemotherapy is still ongoing, there is clear evidence of cognitive decline in women with breast cancer post-chemotherapy. Cognitive decline is often reported to affect memory, attention, executive functioning and information processing speed.
Studies suggest that incidence of "chemobrain" ranges from 17% - 75% in women who have undergone chemotherapy.This cognitive impairment affects quality of life by impacting patients' ability to concentrate, make decisions and to fulfill family, career, and community responsibilities.
Although there is uncertainty about the mechanisms that can lead to this cognitive decline, there is a pressing need to identify interventions that will alleviate its symptoms and help breast cancer survivors recover their cognitive functioning and resume their roles and activities at the pre-cancer level.
Brain plasticity refers to the brain's capacity for physical and functional change; it is this capacity that explains how experience induces learning throughout life. On the basis of a growing body of literature in the fields of psychophysics, neurology, neuropsychology, and brain plasticity, we hypothesize that the brain processing machinery can be refined, elaborated, and strengthened through rigorous training and learning. The purpose of this study is to investigate if such training can improve cognitive functioning.
We hypothesize that continuous active interaction with environments that are demanding to sensory, cognitive, and motor systems, together with imbedded rewards for successful performance will help improve memory and cognitive functioning in patients suffering from "chemobrain".
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Supportive Care|
|Official Title:||Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment, A Pilot Study|
|Study Start Date :||October 2006|
|Actual Primary Completion Date :||June 2008|
|Actual Study Completion Date :||June 2008|
- Examination of the quantitative training program progression data
- Quality of life health assessments
- Functional outcomes assessments
- Perceived stress assessments
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00387062
|United States, California|
|Posit Science Corporation|
|San Francisco, California, United States, 94104|
|Principal Investigator:||Henry W Mahncke, PhD||Posit Science Corporation|