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Somatosensory Processing in Depression

This study has been withdrawn prior to enrollment.
H. Lundbeck A/S
Information provided by (Responsible Party):
Oliver Pogarell, Ludwig-Maximilians - University of Munich Identifier:
First received: October 10, 2006
Last updated: April 13, 2015
Last verified: April 2015
Aim of this study is to investigate neuronal differences (EEG/evoked potentials; functional MRI) between patients with major depression and healthy controls concerning brain activity after acute pain as well as changes of pain related brain activity during treatment with escitalopram.

Condition Intervention Phase
Depression Procedure: simultaneous EEG/fMRI Device: fMRI Phase 4

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Influence of Escitalopram on Somatosensory Processing in Patients With Major Depression

Further study details as provided by Oliver Pogarell, Ludwig-Maximilians - University of Munich:

Primary Outcome Measures:
  • changes in evoked potentials/functional MRI from baseline to week 4 [ Time Frame: two assessments, at baseline and week 4 ]

Enrollment: 0
Study Start Date: October 2006
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Treatment as usual
simultaneous EEG/fMRI
Procedure: simultaneous EEG/fMRI
fMRI/EEG recordings
Device: fMRI


Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Psychiatric in or outpatients with acute depressive episode
  • Indication for pharmacological treatment

Exclusion Criteria:

  • Acute suicidal tendency
  • Neurological or severe somatic disorders
  • Women during pregnancy or lactation
  Contacts and Locations
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Please refer to this study by its identifier: NCT00386893

Department of Psychiatry and Clin. Radiology, Ludwig-Maximilian-University
Munich, Bavaria, Germany, D - 80336
Sponsors and Collaborators
Ludwig-Maximilians - University of Munich
H. Lundbeck A/S
Principal Investigator: Ulrich Hegerl, MD Department of Psychiatry, Ludwig-Maximilians-University
Principal Investigator: Oliver Pogarell, MD Department of Psychiatry, Ludwig-Maximilians-University
  More Information

Responsible Party: Oliver Pogarell, Investigator, Ludwig-Maximilians - University of Munich Identifier: NCT00386893     History of Changes
Other Study ID Numbers: ESC_03082005
Study First Received: October 10, 2006
Last Updated: April 13, 2015

Additional relevant MeSH terms:
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders processed this record on September 21, 2017