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Metabolic Study of Concentric and Eccentric Muscle Training

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ClinicalTrials.gov Identifier: NCT00386854
Recruitment Status : Completed
First Posted : October 12, 2006
Last Update Posted : October 12, 2006
Sponsor:
Information provided by:
Vorarlberg Institute for Vascular Investigation and Treatment

Brief Summary:
The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.

Condition or disease Intervention/treatment Phase
Lipid Metabolism Insulin Resistance Inflammation Behavioral: physical training Not Applicable

Detailed Description:

Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans.

Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).


Study Type : Interventional  (Clinical Trial)
Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Educational/Counseling/Training
Study Start Date : April 2003
Study Completion Date : August 2003



Primary Outcome Measures :
  1. Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.

Secondary Outcome Measures :
  1. Metabolic and anti-inflammatory effects induced by concentric muscle exercise.


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Ages Eligible for Study:   30 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy men and women
  • age over 30 years

Exclusion Criteria:

  • previous systematic endurance training (≥3 times per week ≥30 min)
  • body mass index >30 kg/m2
  • heavy smoking (>20 cigarettes per day)
  • regular alcohol consumption >60g per day
  • established musculoskeletal disease
  • history of cardiovascular disease
  • diabetes mellitus
  • unwillingness to stay in the area for the whole study period

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00386854


Locations
Austria
Vorarlberg Institute of Vascular Investigation and Treatment
Feldkirch, Vorarlberg, Austria, 6807
Sponsors and Collaborators
Vorarlberg Institute for Vascular Investigation and Treatment
Investigators
Principal Investigator: Heinz Drexel, MD Vorarlberg Institut of Vascular Investigation and Treatment, Academic Teaching Hospital, Austria

ClinicalTrials.gov Identifier: NCT00386854     History of Changes
Other Study ID Numbers: K01-2003-1
First Posted: October 12, 2006    Key Record Dates
Last Update Posted: October 12, 2006
Last Verified: October 2006

Keywords provided by Vorarlberg Institute for Vascular Investigation and Treatment:
exercise
lipid metabolism
lipoproteins
insulin resistance
inflammation

Additional relevant MeSH terms:
Inflammation
Insulin Resistance
Pathologic Processes
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases