This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Fish Oil (Omega 3), Immune Function, and Mood

This study has been completed.
National Institute on Aging (NIA)
Information provided by (Responsible Party):
Janice Kiecolt-Glaser, Ohio State University Identifier:
First received: October 10, 2006
Last updated: November 13, 2012
Last verified: November 2012
This study is designed to examine the effects of fish oil on immune function and mood.

Condition Intervention Phase
Inflammation Dietary Supplement: Omega 3 (Fish Oil) Supplementation Dietary Supplement: Placebo Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Omega-3 Dietary Supplementation, Immune Function, and Mood

Resource links provided by NLM:

Further study details as provided by Janice Kiecolt-Glaser, Ohio State University:

Primary Outcome Measures:
  • Serum ln(TNF-a) [ Time Frame: Baseline & 4 months ]
    log-transformed serum Tumor Necrosis Factor-alpha (TNF-alpha)

  • Serum ln(IL-6) [ Time Frame: Baseline & 4 months ]
    log-transformed serum Interleukin-6 (IL-6)

  • ln(CES-D) [ Time Frame: Baseline & 4 months ]

    log-transformed Center for Epidemiologic Studies Depression Scale (CES-D) score The CES-D is a self-report scale designed to measure current symptoms of depression rated on a four-point likert scale.

    Scores range from 0-60, with higher scores indicating a higher frequency of depressive symptoms.

Enrollment: 138
Study Start Date: September 2006
Study Completion Date: February 2011
Primary Completion Date: February 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
1.25 g/d
Dietary Supplement: Omega 3 (Fish Oil) Supplementation
1.25 g or 2.496 g daily for 4 months
Experimental: 2
2.496 g/d
Dietary Supplement: Omega 3 (Fish Oil) Supplementation
1.25 g or 2.496 g daily for 4 months
Placebo Comparator: 3 Dietary Supplement: Placebo
matching placebo capsule daily for 4 months

Detailed Description:

The beneficial effects of fish oil (or eating fish more frequently) include reductions in triglycerides, blood pressure, and heart rate, as well as increases in HDL cholesterol, the "good" type of cholesterol. In addition, certain aspects of immune function also appear to show favorable responses to fish oil supplementation, and some studies suggest that fish oil helps to improve mood and decrease depression.

This study is designed to examine how supplementation with omega-3 polyunsaturated fatty acids (key fish oil components) affects aspects of your immune response, and your mood; because some research suggests that people who eat more fish may do better during stressful times, the study will also examine how fish oil affects your immune response to stress, certain stress hormone responses, and your psychological response to stress.

For detailed information about the study, please visit our website at


Ages Eligible for Study:   40 Years to 88 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Recruiting men and women ages 40-88 from the Greater Columbus Ohio area. Participation involves taking capsules for 4 months and completing 6 appointments (for a total of 19.5 hours) at Ohio State.

Inclusion Criteria:

  • Healthy men and women
  • NOT currently taking any sort of fish oil or omega 3 supplement

Exclusion Criteria:

  • Use of blood pressure medicines, cholesterol-lowering drugs, steroids, or antidepressants
  • Certain lifestyle habits such as smoking or exercising vigorously for 2 or more hours a week may also exclude applicants from participating
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00385723

United States, Ohio
The Ohio State University
Columbus, Ohio, United States, 43210
Sponsors and Collaborators
Ohio State University
National Institute on Aging (NIA)
Principal Investigator: Janice K. Kiecolt-Glaser Ohio State University
  More Information

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Janice Kiecolt-Glaser, Professor of Psychiatry and Psychology, Ohio State University Identifier: NCT00385723     History of Changes
Other Study ID Numbers: AG0087
R01AG029562 ( U.S. NIH Grant/Contract )
Study First Received: October 10, 2006
Results First Received: August 28, 2012
Last Updated: November 13, 2012

Keywords provided by Janice Kiecolt-Glaser, Ohio State University:

Additional relevant MeSH terms:
Pathologic Processes processed this record on September 21, 2017