RESTORE-IT-Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients With a History of Atherosclerotic Disease
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00385385|
Recruitment Status : Unknown
Verified April 2007 by ActivBiotics.
Recruitment status was: Recruiting
First Posted : October 9, 2006
Last Update Posted : April 30, 2007
|Condition or disease||Intervention/treatment||Phase|
|Coronary Artery Disease Cerebrovascular Disease Peripheral Vascular Disease||Drug: Rifalazil||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||72 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Randomized Evaluation of Short-Term Rifalazil Treatment on Carotid Atherosclerosis and Intima Media Thickness|
|Study Start Date :||October 2006|
|Study Completion Date :||September 2008|
- To evaluate the treatment with Rifalazil versus placebo on high-resolution magnetic resonance imaging (MRI) determined by the normalized wall index (NWI) over a segment of the carotid artery at Day 180.
- NWI is defined as the wall area (WA) over the length of the arterial segment studied divided by the sum of the wall area plus the lumen area (LA) over the length of the arterial segment studied [NWI = WA / (WA + LA)].
- To evaluate the effect of rifalazil versus placebo on carotid intima media thickness (IMT), and carotid plaque composition by ultrasound and MRI and to determine the overall safety of a 12 week regimen of rifalazil administered once weekly.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00385385
|Contact: Emelia Klonowski Klonowskiemail@example.com|
|United States, Michigan|
|Thoracic & Cardiovascular Healthcare Foundation||Recruiting|
|Lansing, Michigan, United States, 48910|
|United States, New York|
|St. Francis Hospital||Recruiting|
|Roslyn, New York, United States, 11576|
|Stony Brook University Medical Center||Recruiting|
|Stony Brook, New York, United States, 11794|
|United States, Texas|
|Baylor College of Medicine||Recruiting|
|Houston, Texas, United States, 77030|
|United States, Washington|
|Swedish Medical Center||Recruiting|
|Seattle, Washington, United States, 98122|
|Robarts Research Institute||Recruiting|
|London, Ontario, Canada|