Expressive Writing in Male Infertility

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00385346
Recruitment Status : Completed
First Posted : October 9, 2006
Last Update Posted : June 30, 2010
Information provided by:
University Hospital, Bonn

Brief Summary:
The purpose of this study is to determine whether expressive writing can be effective in improving the well-being and sperm quality in patients with male infertility.

Condition or disease Intervention/treatment Phase
Infertility, Male Behavioral: Expressive writing Not Applicable

Detailed Description:

Expressive writing is a therapeutic intervention designed by the psychologist James W. Pennebaker. Individuals write on three days for about 20 minutes about particularly stressful experiences in their life. Several studies showed that expressive writing can have beneficial effects on the frequency of health care utilization and well-being. Particularly in patients with rheumatism, kidney cancer and posttraumatic stress disorder expressive writing showed an positive effect on subjective well-being. Furthermore, in several studies expressive writing showed a positive effect on immune parameters.

As many studies suggest an important negative effect of stress on well-being and sperm parameters in male infertility, we want to investigate the effect of expressive writing in male infertility.The expressive writing condition is compared to a non emotional writing condition, in which individuals write about mainly non emotional topics such as time management. In this randomized-controlled trial subjects were allocated sequentially by block wise randomization (block size of 4). For randomization a computer generated random list was used. The allocation was concealed in a series of numbered sealed envelopes. The envelope was opened immediately before the first writing session.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 56 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Expressive Writing as a Therapeutic Intervention in Male Infertility
Study Start Date : November 2006
Actual Primary Completion Date : June 2008
Actual Study Completion Date : February 2009

Arm Intervention/treatment
Experimental: A 1
Expressive writing
Behavioral: Expressive writing
Patients in the intervention group write on three day for 20 minutes about highly emotional topics In the control group patients write on three days for 20 minutes about topics with relatively low emotional involvement such as diet, time management and sport.

Primary Outcome Measures :
  1. Scores on rating scale for perceived stress in infertility [ Time Frame: 3 months ]

Secondary Outcome Measures :
  1. Scores on rating scale for personality dimensions [ Time Frame: 3 months ]
  2. Sperm parameters [ Time Frame: 3-12 months ]
  3. Score on rating scale for coping [ Time Frame: 3 months ]

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Male infertile patients with a pathological spermiogram according to WHO criteria

Exclusion Criteria:

  • Drugs affecting sperm quality
  • Patients with chromosomal anomalies affecting sperm quality (e.g. Klinefelter- Syndrome)
  • Severe Psychiatric disorder defined as psychotic disorder (schizophrenia, bipolar disorder) or substance-related disorder
  • Patients currently in psychotherapeutic or psychiatric therapy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00385346

University of Bonn, Department of Psychosomatic Medicine
Bonn, Germany, 53105
Sponsors and Collaborators
University Hospital, Bonn
Study Chair: Reinhard Liedtke, MD University of Bonn, Department of Psychosomatic Medicine


Responsible Party: Prof. Dr. R. Liedtke, Department of Psychosomatic Medicine and Psychotherapy, University of Bonn Identifier: NCT00385346     History of Changes
Other Study ID Numbers: Lfd.Nr.068/06
First Posted: October 9, 2006    Key Record Dates
Last Update Posted: June 30, 2010
Last Verified: September 2009

Keywords provided by University Hospital, Bonn:
Expressive writing
Male infertility

Additional relevant MeSH terms:
Infertility, Male
Genital Diseases, Male
Genital Diseases, Female