This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Role of B2 Adrenergic Receptors in Labor Pain

This study has been completed.
Information provided by:
Columbia University Identifier:
First received: October 5, 2006
Last updated: October 1, 2010
Last verified: October 2010
We wish to understand why labor is more painful for some women compared to others.We will study whether a woman's baseline pain sensitivity, beta2 adrenergic receptor genotype is related to her pain in labor for the birth of a first child.

Pain Pain Threshold Labour Pain

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Role of B2 Adrenergic Receptors in Labor Pain

Further study details as provided by Columbia University:

Biospecimen Retention:   Samples With DNA
DNA identified by subject number will be retained for analysis.

Enrollment: 150
Study Start Date: September 2006
Study Completion Date: January 2009
Primary Completion Date: January 2009 (Final data collection date for primary outcome measure)
Detailed Description:
Other than parity, and infant size, the etiology of the great variability in labor pain us unknown. Previous studies have demonstrated that baseline pain sensitivity is related to postoperative pain and narcotic requirement. We hypothesize that baseline pain sensitivity is related to pain in labor. We will determine baseline sensitivity to heat, cold and pressure as measurement of pain sensitivity. Furthermore, b2 adrenergic genotype has recently been identified as a potential determinant of pain sensitivity. We will determine whether B2 receptor haplotype is an independent predictor of pain experienced in labor.

Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Nuliparous women anticipating NSVD

Inclusion Criteria:

  • nulliparous women
  • Third trimester of pregnancy on enrollment

Exclusion Criteria:

  • Chronic Pain
  • Pain medication utilization
  • Large for gestational age baby
  • Small for gestational age baby
  • Systemic illness
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00385294

United States, New York
Columbia University
New York, New York, United States, 10032
Sponsors and Collaborators
Columbia University
Principal Investigator: Pamela D. Flood, M.D. Columbia University
  More Information

Responsible Party: Pamela Flood, Columbia University Identifier: NCT00385294     History of Changes
Other Study ID Numbers: AAAB3535
Study First Received: October 5, 2006
Last Updated: October 1, 2010

Keywords provided by Columbia University:

Additional relevant MeSH terms:
Labor Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs processed this record on September 20, 2017