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Role of B2 Adrenergic Receptors in Labor Pain

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00385294
First Posted: October 9, 2006
Last Update Posted: October 4, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Columbia University
  Purpose
We wish to understand why labor is more painful for some women compared to others.We will study whether a woman's baseline pain sensitivity, beta2 adrenergic receptor genotype is related to her pain in labor for the birth of a first child.

Condition
Pain Pain Threshold Labour Pain

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Role of B2 Adrenergic Receptors in Labor Pain

Further study details as provided by Columbia University:

Biospecimen Retention:   Samples With DNA
DNA identified by subject number will be retained for analysis.

Enrollment: 150
Study Start Date: September 2006
Study Completion Date: January 2009
Primary Completion Date: January 2009 (Final data collection date for primary outcome measure)
Detailed Description:
Other than parity, and infant size, the etiology of the great variability in labor pain us unknown. Previous studies have demonstrated that baseline pain sensitivity is related to postoperative pain and narcotic requirement. We hypothesize that baseline pain sensitivity is related to pain in labor. We will determine baseline sensitivity to heat, cold and pressure as measurement of pain sensitivity. Furthermore, b2 adrenergic genotype has recently been identified as a potential determinant of pain sensitivity. We will determine whether B2 receptor haplotype is an independent predictor of pain experienced in labor.
  Eligibility

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Nuliparous women anticipating NSVD
Criteria

Inclusion Criteria:

  • nulliparous women
  • Third trimester of pregnancy on enrollment

Exclusion Criteria:

  • Chronic Pain
  • Pain medication utilization
  • Large for gestational age baby
  • Small for gestational age baby
  • Systemic illness
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00385294


Locations
United States, New York
Columbia University
New York, New York, United States, 10032
Sponsors and Collaborators
Columbia University
Investigators
Principal Investigator: Pamela D. Flood, M.D. Columbia University
  More Information

Publications:
Responsible Party: Pamela Flood, Columbia University
ClinicalTrials.gov Identifier: NCT00385294     History of Changes
Other Study ID Numbers: AAAB3535
First Submitted: October 5, 2006
First Posted: October 9, 2006
Last Update Posted: October 4, 2010
Last Verified: October 2010

Keywords provided by Columbia University:
Genetic
pain
obstetrical

Additional relevant MeSH terms:
Labor Pain
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs