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The Effect of Beer, Red Wine and Fruit Juice on Blood Vessel Function in Persons With Cardiovascular Disease

This study has been completed.
Information provided by:
Aalborg Universitetshospital Identifier:
First received: September 28, 2006
Last updated: January 29, 2009
Last verified: January 2009
To study the effect of red wine, beer and fruit juice on endothelial function in patients with coronary Heart disease.

Condition Intervention Phase
Coronary Heart Disease Behavioral: Moderate daily consumption of Red wine Behavioral: Moderate daily consumption of beer Behavioral: Moderate consumption of fruit juice rich in polyphenolics Early Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: The Effect of Alcohol and Polyphenolic Compounds on Endothelial Function

Further study details as provided by Aalborg Universitetshospital:

Primary Outcome Measures:
  • Changes in flow-mediated vasodilation after 2 weeks intervention compared with baseline

Secondary Outcome Measures:
  • Lipid status after 2 weeks intervention compared with baseline
  • Effects in Coagulation factors after 2 weeks intervention
  • Effects on markers of inflammation after 2 weeks intervention
  • Effects on markers of endothelial function after 2 weeks intervention
  • Changes in the overall antioxidant activity in plasma after 2 weeks intervention

Enrollment: 49
Study Start Date: October 2006

Ages Eligible for Study:   30 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Men or postmenopausal women with stable coronary heart disease
  • Coronary heart disease should be verified by coronary angiography with at least 50% stenosis in at least one coronary vessel.

Exclusion Criteria:

  • Patients with myocardial infarction within the last tree months
  • Persons with a present or earlier alcohol abuse
  • Persons with a present or earlier drug abuse
  • Person with malign disease
  • Persons, that we consider unsuitable to carry through the examines.
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Please refer to this study by its identifier: NCT00382551

Department of Cardiology, Aalborg Hospital, Science and Innovation Center
Aalborg, Denmark, 9000
Sponsors and Collaborators
Aalborg Universitetshospital
Study Director: Erik B Schmidt, Professor Department of Cardiology, Aalborg Hospital , Aarhus University Hospital
  More Information Identifier: NCT00382551     History of Changes
Other Study ID Numbers: VN-20060043
Study First Received: September 28, 2006
Last Updated: January 29, 2009

Keywords provided by Aalborg Universitetshospital:
Red wine
Endothelial function
Flow-mediated vasodilation
Cardiovascular disease

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases processed this record on September 21, 2017