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The Effect of Beer, Red Wine and Fruit Juice on Blood Vessel Function in Persons With Cardiovascular Disease

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00382551
First Posted: September 29, 2006
Last Update Posted: January 30, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Aalborg Universitetshospital
  Purpose
To study the effect of red wine, beer and fruit juice on endothelial function in patients with coronary Heart disease.

Condition Intervention Phase
Coronary Heart Disease Behavioral: Moderate daily consumption of Red wine Behavioral: Moderate daily consumption of beer Behavioral: Moderate consumption of fruit juice rich in polyphenolics Early Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: The Effect of Alcohol and Polyphenolic Compounds on Endothelial Function

Further study details as provided by Aalborg Universitetshospital:

Primary Outcome Measures:
  • Changes in flow-mediated vasodilation after 2 weeks intervention compared with baseline

Secondary Outcome Measures:
  • Lipid status after 2 weeks intervention compared with baseline
  • Effects in Coagulation factors after 2 weeks intervention
  • Effects on markers of inflammation after 2 weeks intervention
  • Effects on markers of endothelial function after 2 weeks intervention
  • Changes in the overall antioxidant activity in plasma after 2 weeks intervention

Enrollment: 49
Study Start Date: October 2006
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Men or postmenopausal women with stable coronary heart disease
  • Coronary heart disease should be verified by coronary angiography with at least 50% stenosis in at least one coronary vessel.

Exclusion Criteria:

  • Patients with myocardial infarction within the last tree months
  • Persons with a present or earlier alcohol abuse
  • Persons with a present or earlier drug abuse
  • Person with malign disease
  • Persons, that we consider unsuitable to carry through the examines.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00382551


Locations
Denmark
Department of Cardiology, Aalborg Hospital, Science and Innovation Center
Aalborg, Denmark, 9000
Sponsors and Collaborators
Aalborg Universitetshospital
Investigators
Study Director: Erik B Schmidt, Professor Department of Cardiology, Aalborg Hospital , Aarhus University Hospital
  More Information

ClinicalTrials.gov Identifier: NCT00382551     History of Changes
Other Study ID Numbers: VN-20060043
First Submitted: September 28, 2006
First Posted: September 29, 2006
Last Update Posted: January 30, 2009
Last Verified: January 2009

Keywords provided by Aalborg Universitetshospital:
Alcohol
Red wine
Endothelial function
Flow-mediated vasodilation
Cardiovascular disease

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Vascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases