Trial record 1 of 17 for:    "Vocal Cord Paralysis"
Previous Study | Return to List | Next Study

Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2007 by Hadassah Medical Organization.
Recruitment status was  Recruiting
Information provided by:
Hadassah Medical Organization Identifier:
First received: September 28, 2006
Last updated: May 12, 2008
Last verified: November 2007
Vocal cord paralysis is a common cause of congenital stridor and airway obstruction. In this study we plan to identify the genetic locus of the genes in two extended families who suffer of the disease.

Vocal Cord Paralysis

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

Resource links provided by NLM:

Further study details as provided by Hadassah Medical Organization:

Biospecimen Retention:   Samples With DNA
DNA prepared from blood

Estimated Enrollment: 60
Study Start Date: May 2005
Estimated Study Completion Date: December 2007
Detailed Description:
In a number of families suffering of familial vocal cord paralysis it has previously been shown that the disease is inherited autosomal dominant. In one of the families the gene coding for the disease was located on chromosome 6q16. We will be analyzing 2 extended families with familial vocal cord paralysis to define their genetic defect leading to the disease. All family members will undergo a laryngoscopy to determine the extent of paralysis. For all family members we will isolate DNA and determine their microsatellite polymorphism on chromosome 6q16. If the results are negative we will continue the study and perform a whole genome scan to localize the gene(s) involved.

Ages Eligible for Study:   10 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Families suffering of familial vocal cord paralysis

Inclusion Criteria:

  • members of families suffering of familial vocal cord paralysis

Exclusion Criteria:

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00382369

Contact: Eitan Kerem, MD 972-2-5844430

Hadassah-Hebrew University Medical Center, Mt Scopus Recruiting
Jerusalem, Israel, 24035
Contact: Arik Tzukert, DMD    00 972 2 6776095   
Contact: Hadas Lemberg, PhD    00 972 2 6777572   
Sub-Investigator: Ariela Simon, MD         
Sponsors and Collaborators
Hadassah Medical Organization
Study Director: Eitan Kerem, MD Hadassah MO
Principal Investigator: Batsheva Kerem, PhD Hebrew University Jerusalem
  More Information

Responsible Party: Prof Eitan Kerem, Hadassah Medical Organization Identifier: NCT00382369     History of Changes
Other Study ID Numbers: VOCALCORD-HMO-CTIL 
Study First Received: September 28, 2006
Last Updated: May 12, 2008
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Hadassah Medical Organization:
familial vocal cord paralysis
genetic screening

Additional relevant MeSH terms:
Vocal Cord Paralysis
Cranial Nerve Diseases
Laryngeal Diseases
Nervous System Diseases
Neurologic Manifestations
Otorhinolaryngologic Diseases
Respiratory Tract Diseases
Signs and Symptoms
Vagus Nerve Diseases processed this record on May 01, 2016