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Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00382369
First Posted: September 29, 2006
Last Update Posted: February 27, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Kerem Eithan, Hadassah Medical Organization
  Purpose
Vocal cord paralysis is a common cause of congenital stridor and airway obstruction. In this study we plan to identify the genetic locus of the genes in two extended families who suffer of the disease.

Condition
Vocal Cord Paralysis

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

Resource links provided by NLM:


Further study details as provided by Kerem Eithan, Hadassah Medical Organization:

Biospecimen Retention:   Samples With DNA
DNA prepared from blood

Enrollment: 11
Actual Study Start Date: June 1, 2008
Study Completion Date: December 29, 2008
Primary Completion Date: November 17, 2008 (Final data collection date for primary outcome measure)
Detailed Description:
In a number of families suffering of familial vocal cord paralysis it has previously been shown that the disease is inherited autosomal dominant. In one of the families the gene coding for the disease was located on chromosome 6q16. We will be analyzing 2 extended families with familial vocal cord paralysis to define their genetic defect leading to the disease. All family members will undergo a laryngoscopy to determine the extent of paralysis. For all family members we will isolate DNA and determine their microsatellite polymorphism on chromosome 6q16. If the results are negative we will continue the study and perform a whole genome scan to localize the gene(s) involved.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   10 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Families suffering of familial vocal cord paralysis
Criteria

Inclusion Criteria:

  • members of families suffering of familial vocal cord paralysis

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00382369


Locations
Israel
Hadassah-Hebrew University Medical Center, Mt Scopus
Jerusalem, Israel, 24035
Sponsors and Collaborators
Hadassah Medical Organization
Investigators
Study Director: Eitan Kerem, MD Hadassah MO
Principal Investigator: Batsheva Kerem, PhD Hebrew University Jerusalem
  More Information

Publications:
Responsible Party: Kerem Eithan, Professor, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00382369     History of Changes
Other Study ID Numbers: VOCALCORD-HMO-CTIL
First Submitted: September 28, 2006
First Posted: September 29, 2006
Last Update Posted: February 27, 2017
Last Verified: February 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Kerem Eithan, Hadassah Medical Organization:
familial vocal cord paralysis
genetic screening

Additional relevant MeSH terms:
Paralysis
Vocal Cord Paralysis
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Laryngeal Diseases
Respiratory Tract Diseases
Otorhinolaryngologic Diseases
Vagus Nerve Diseases
Cranial Nerve Diseases