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IOP-Lowering Efficacy of Brinzolamide 1.0% Added to Travoprost 0.004%/Timolol 0.5% Fixed Combination as Adjunctive Therapy

This study has been completed.
Information provided by (Responsible Party):
Alcon Research Identifier:
First received: September 27, 2006
Last updated: November 17, 2016
Last verified: April 2008
Uncontrolled glaucoma patients being treated with a prostaglandin agent alone or in combination with adjunctive drugs in fixed or unfixed combinations, will be switched from their current therapy to travoprost/timolol fixed combination and either Azopt or placebo

Condition Intervention Phase
Drug: Azopt
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: IOP-Lowering Efficacy of Brinzolamide 1.0% Added to Travoprost 0.004%/Timolol 0.5% Fixed Combination as Adjunctive Therapy

Resource links provided by NLM:

Further study details as provided by Alcon Research:

Primary Outcome Measures:
  • IOP lowering

Secondary Outcome Measures:
  • safety

Estimated Enrollment: 195
Study Start Date: September 2006
Study Completion Date: August 2007
Primary Completion Date: August 2007 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Glaucoma

Exclusion Criteria:

  • Under 18
  Contacts and Locations
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Please refer to this study by its identifier: NCT00382226

Australia, New South Wales
Sydney Study Site
Sydney, New South Wales, Australia, 2000
Sponsors and Collaborators
Alcon Research
Study Director: Mark Jasek Alcon Research
  More Information

Responsible Party: Alcon Research Identifier: NCT00382226     History of Changes
Other Study ID Numbers: CM-05-10
Study First Received: September 27, 2006
Last Updated: November 17, 2016

Keywords provided by Alcon Research:

Additional relevant MeSH terms:
Ocular Hypertension
Eye Diseases
Carbonic Anhydrase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Physiological Effects of Drugs
Anti-Arrhythmia Agents
Antihypertensive Agents processed this record on April 28, 2017