University of Michigan "Nephrology Research BioBank"

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT00381121
Recruitment Status : Recruiting
First Posted : September 27, 2006
Last Update Posted : October 24, 2018
Information provided by (Responsible Party):
Matthias Kretzler, University of Michigan

Brief Summary:
The purpose of the study is to create a Nephrology Tissue Biobank enabling the study of kidney disease from the perspectives of epidemiology, genetics and molecular biology.

Condition or disease
Chronic Kidney Disease

Detailed Description:

Each year chronic kidney disease (CKD) claims the lives of millions of people worldwide. Costs for patient care are in excess of 2.4 billion dollars in the US alone. At the moment most kidney diseases are of unknown etiology, are classified according to a microscopic description of the kidney tissue obtained on biopsy and are treated with non-specific therapies.

Each kidney contains millions of filter units called nephrons. The nephron consists of a glomerulus and a tubule. The glomerulus filters the blood of waste products, while retaining larger molecules that are required for the body to function properly. The filtered fluid then passes through the tubule, where salts, acids and water are regulated to keep the body in a normal metabolic state. After the filtered fluid passes through the tubule it is collected in the bladder as urine. Diseases, which affect the glomeruli or tubules result in kidney damage. Once kidney function is lost it is generally not recoverable and the only option for a patient's survival is dialysis or transplantation.

The purpose of this study is to provide a platform, which will enable researchers with different areas of expertise, to investigate the molecular markers and pathways of kidney disease and its progression. Our goal is to increase our understanding of kidney health issues and to develop new prevention and treatment strategies which will be shared with the medical community and the public.

Study description:

Individuals seen in the nephrology clinic at the University of Michigan will be eligible to enroll in this study. Their clinical data will be recorded, blood and urine samples will be collected and if a biopsy is performed as a part of their standard medical care then a small sample will be reserved for use in the study after all pathological evaluations required for patient care are completed. Biological samples will be available for biochemical, molecular biological and genetic testing and for correlation of these parameters to the individuals clinical data in future studies.


Advances in the understanding of kidney disease may 1) provide methods of early detection of disease, 2) identify molecular markers that will help physician prescribe the most appropriate and beneficial treatments, 3) identify targets for the development of new treatments, and 4) decrease the enormous cost of caring for individuals with CKD.


  1. Create a biobank enabling the study of kidney disease from the perspectives of epidemiology, genetics and molecular biology.
  2. Create a resource for the study of kidney disease, which will enable the researchers at the University of Michigan to work collaboratively toward the elucidation of the molecular pathways, which cause kidney disease.

Study Type : Observational
Estimated Enrollment : 420 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Michigan Nephrology Research BioBank for Molecular Analysis of Renal Disease "Nephrology Research BioBank"
Study Start Date : September 2006
Estimated Primary Completion Date : August 2026
Estimated Study Completion Date : August 2026

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Diseases

Kidney disease cohort
Individuals with a clinically indicated biopsy are recruited and/or surplus tissue that remains from past clinical interventions is obtained.

Biospecimen Retention:   Samples With DNA
Tissue, blood, urine

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Renal disease patients undergoing diagnostic workup

Inclusion Criteria:

  • Men, women and children undergoing kidney and/or pancreas biopsy at the University of Michigan

Exclusion Criteria:

  • Individuals not willing to provide consent (for prospective biopsy)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00381121

Contact: Chrysta Lienczewsky 734-764-2924

United States, Michigan
University of Michigan Health System Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Chrysta Lienczewski    734-764-2924   
Contact: Matthias Kretzler, MD    734-615-5757   
Principal Investigator: Matthias Kretzler, MD         
Sponsors and Collaborators
University of Michigan
Principal Investigator: Matthias Kretzler,, MD University of Michigan

Responsible Party: Matthias Kretzler, Professor of Medicine, University of Michigan Identifier: NCT00381121     History of Changes
Other Study ID Numbers: HUM 4729
First Posted: September 27, 2006    Key Record Dates
Last Update Posted: October 24, 2018
Last Verified: October 2018

Keywords provided by Matthias Kretzler, University of Michigan:
Tissue Biobank
molecular markers
molecular pathways

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency