PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

This study has been completed.
Information provided by:
Danish Headache Center Identifier:
First received: September 21, 2006
Last updated: May 29, 2008
Last verified: May 2008
To investigate headache score and accompanying symptoms during and after infusion of PACAP38 i migraine patients

Condition Intervention
Migraine Without Aura
Drug: PACAP38

Study Type: Interventional
Official Title: Basic Scientific Research Investigating PACAP38 Headache Inducing Effects in Migraine Patients

Resource links provided by NLM:

Further study details as provided by Danish Headache Center:

Enrollment: 12
Study Start Date: November 2006
Study Completion Date: November 2007
Primary Completion Date: November 2007 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: PACAP38
    10 pmol/kg/min given one time
Detailed Description:

To investigate headache score and accompanying symptoms during and after infusion of PACAP38

Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial artery (RA)


Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Healthy migraine patient without aura
  • Aged 18-50
  • 50-100 kg
  • Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria:

  • Tension type headache more than five times/month
  • Other primary headaches
  • Daily medication except contraceptives
  • Drug taken within 4 times the halflife for the specific drug except contraceptives
  • Pregnant or lactating women
  • Exposure to radiation within the last year
  • Headache within the last 48 hours before start of trial
  • Hypertension
  • Hypotension
  • Respiratory or cardiac disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT00380263

Dansih Headache Center
Glostrup, Denmark, 2600
Sponsors and Collaborators
Danish Headache Center
Principal Investigator: Henrik Schytz, MD Danish Headache Center
  More Information

No publications provided

Responsible Party: Henrik Schytz/MD, Danish Headache Center Identifier: NCT00380263     History of Changes
Other Study ID Numbers: KA-20060087 
Study First Received: September 21, 2006
Last Updated: May 29, 2008
Health Authority: Denmark: Danish Medicines Agency

Additional relevant MeSH terms:
Migraine without Aura
Brain Diseases
Central Nervous System Diseases
Headache Disorders
Headache Disorders, Primary
Migraine Disorders
Nervous System Diseases
Pituitary Adenylate Cyclase-Activating Polypeptide
Cardiovascular Agents
Growth Substances
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses
Vasodilator Agents processed this record on February 09, 2016