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Eye and Immunogenetic Features of Sarcoidosis

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00379275
First Posted: September 21, 2006
Last Update Posted: July 2, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institutes of Health Clinical Center (CC)
  Purpose

This study will evaluate patients with sarcoidosis to understand how the disease affects the body. Sarcoidosis is a disease that results from inflammation of body tissues. The lungs, lymph nodes in the chest, skin and eyes are most commonly affected. As the disease progresses, small lumps, or granulomas, appear in the affected tissues. In most cases, the granulomas clear up, but in cases where they do not heal and disappear, the tissues tend to remain inflamed. Eye inflammation (uveitis) associated with sarcoidosis can cause various eye diseases, sometimes leading to blindness. This study will examine the clinical, immunological and genetic features of ocular sarcoidosis.

Patients 6 years of age and older with sarcoidosis may be eligible for this study. Candidates are screened with the following procedures:

  • Completion of a questionnaire with medical, social and demographic information
  • Blood draw for laboratory tests
  • Complete eye examination, including measurement of eye pressure and dilation of the pupils to examine the back of the eye. Fluorescein angiography may be done. This test involves injecting a dye into a vein in the arm. The dye travels to the blood vessels in the eyes. A camera flashes a blue light into the eye and takes pictures of the retina that show whether the dye has leaked from the blood vessels into the retina. Other photographs of the eye may also be taken using a special camera.

Participants are followed in conjunction with their local eye doctor as required by the status of their disease. Patients whose disease is stable are seen for an initial examination and followed every 12 months for 3 years.


Condition
Sarcoidosis Uveitis

Study Type: Observational
Official Title: Ocular and Immuno-Genetic Manifestations of Sarcoidosis

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 100
Study Start Date: September 18, 2006
Estimated Study Completion Date: December 10, 2007
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   6 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
  • INCLUSION CRITERIA:

    1. Participants must be at least 6 years old
    2. Participants must have biopsy-proven sarcoidosis
    3. Participant must be able to consent to participating in the protocol
    4. For minors, consent by an adult will be necessary

EXCLUSION CRITERIA:

We will exclude participants who are unable or unwilling to give blood at the designated times in the protocol

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00379275


Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Eye Institute (NEI)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00379275     History of Changes
Other Study ID Numbers: 060239
06-EI-0239
First Submitted: September 20, 2006
First Posted: September 21, 2006
Last Update Posted: July 2, 2017
Last Verified: December 10, 2007

Keywords provided by National Institutes of Health Clinical Center (CC):
Sarcoidosis
Uveitis
Pulmonary Sarcoidosis
HLA-Typing
Cytokines
Serum Markers

Additional relevant MeSH terms:
Uveitis
Sarcoidosis
Uveal Diseases
Eye Diseases
Lymphoproliferative Disorders
Lymphatic Diseases