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Sensitization in Osteoarthritic Knees

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ClinicalTrials.gov Identifier: NCT00379184
Recruitment Status : Completed
First Posted : September 21, 2006
Last Update Posted : March 31, 2014
Aalborg University
Information provided by (Responsible Party):
Northern Orthopaedic Division, Denmark

Brief Summary:

Musculoskeletal pains represent a major part of pain complaints in patients. Moreover, the treatment of musculoskeletal pain conditions by currently available drugs is not optimal (Curatolo and Bogduk 2001). Thus, deep pain is a diagnostic and therapeutic problem, and further insights into the peripheral and central neurophysiologic mechanisms are necessary to improve diagnosis and therapy and to implement a mechanism-based approach. Peripheral sensitization and central hyper excitability are, most likely the important factors for chronic musculoskeletal pain and in particular osteoarthritis (OA).

The focus of this project is to study the involvement of peripheral and central sensitization underlying deep tissue hyperalgesia and referred pain in male and female OA patients.

Adequate quantitative sensory testing assessment techniques for measuring hyper excitability are needed to investigate, in more detail the mechanisms involved in generating the sensitization in OA patients.

Condition or disease

  Show Detailed Description

Study Type : Observational
Actual Enrollment : 72 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Quantitative Assessment of Central Sensitization in Osteoarthritis Patients
Study Start Date : September 2006
Primary Completion Date : April 2009
Study Completion Date : June 2009

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Osteoarthritis patients scheduled for Total Knee Arthroplasty.
Osteoarthritis patients not scheduled for Total Knee Arthroplasty.
Healthy volunteers

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients with knee OA

Inclusion Criteria:

  • Osteoarthritis in the knee

Exclusion Criteria:

  • No other painful conditions

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00379184

Northern Orthopaedic Division, Clinic Farsoe, Aalborg University Hospital and Aalborg University
Farsoe, Northern Jutland, Denmark
Sponsors and Collaborators
Northern Orthopaedic Division, Denmark
Aalborg University
Principal Investigator: Mogens B Laursen, MD, PhD Northern Orthopaedic Division

Responsible Party: Northern Orthopaedic Division, Denmark
ClinicalTrials.gov Identifier: NCT00379184     History of Changes
Other Study ID Numbers: ON-04-014-MBL
First Posted: September 21, 2006    Key Record Dates
Last Update Posted: March 31, 2014
Last Verified: March 2014

Keywords provided by Northern Orthopaedic Division, Denmark:

Additional relevant MeSH terms:
Joint Diseases
Musculoskeletal Diseases