Sensitization in Osteoarthritic Knees
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|ClinicalTrials.gov Identifier: NCT00379184|
Recruitment Status : Completed
First Posted : September 21, 2006
Last Update Posted : March 31, 2014
Musculoskeletal pains represent a major part of pain complaints in patients. Moreover, the treatment of musculoskeletal pain conditions by currently available drugs is not optimal (Curatolo and Bogduk 2001). Thus, deep pain is a diagnostic and therapeutic problem, and further insights into the peripheral and central neurophysiologic mechanisms are necessary to improve diagnosis and therapy and to implement a mechanism-based approach. Peripheral sensitization and central hyper excitability are, most likely the important factors for chronic musculoskeletal pain and in particular osteoarthritis (OA).
The focus of this project is to study the involvement of peripheral and central sensitization underlying deep tissue hyperalgesia and referred pain in male and female OA patients.
Adequate quantitative sensory testing assessment techniques for measuring hyper excitability are needed to investigate, in more detail the mechanisms involved in generating the sensitization in OA patients.
|Condition or disease|
Show Detailed Description
|Study Type :||Observational|
|Actual Enrollment :||72 participants|
|Official Title:||Quantitative Assessment of Central Sensitization in Osteoarthritis Patients|
|Study Start Date :||September 2006|
|Actual Primary Completion Date :||April 2009|
|Actual Study Completion Date :||June 2009|
Osteoarthritis patients scheduled for Total Knee Arthroplasty.
Osteoarthritis patients not scheduled for Total Knee Arthroplasty.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00379184
|Northern Orthopaedic Division, Clinic Farsoe, Aalborg University Hospital and Aalborg University|
|Farsoe, Northern Jutland, Denmark|
|Principal Investigator:||Mogens B Laursen, MD, PhD||Northern Orthopaedic Division|