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Cardiology Biobank Registry

This study is currently recruiting participants.
Verified July 2017 by Arshed A. Quyyumi, Emory University
Sponsor:
ClinicalTrials.gov Identifier:
NCT00378924
First Posted: September 21, 2006
Last Update Posted: July 26, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
Arshed A. Quyyumi, Emory University
  Purpose

Statement of the Problem:

Over the last several decades, scientists have made great progress in their understanding of cardiovascular disease. Nevertheless, much remains to be learned about the causes, course, and treatment of cardiovascular disease. In order to learn more about this topic, it is important to establish large databases of cardiovascular patients. These databases allows scientists to investigate, in a rigorous and precise manner, those factors that influence cardiovascular disease.

How the Problem Will Be Studied:

In the present study, we intend to establish a large database of cardiovascular patients. More specifically, we will create a database of approximately 12,000 cardiac catheterization and heart failure patients from Emory University Hospital, the Emory Clinic, Crawford Long Hospital, and Grady Memorial Hospital.

We will collect a large amount of data on these patients. Data to be collected will include information on:

  1. medical history of the patient
  2. medical history of the patient's family
  3. health behaviors of the patient
  4. psychological status of the patient
  5. results of procedures the patient undergoes, such as catheterization/angioplasty/bypass
  6. biochemical markers in patient blood samples, including genetic/DNA markers
  7. follow-up information on patient outcomes such as mortality or re-hospitalization

The data noted above will be collected by:

  1. administering questionnaires/interviews to the patients
  2. accessing the medical records of the patients
  3. collecting blood samples from patients which will be analyzed by laboratories for their biochemical content.

Once the data has been collected, we will run a variety of statistical analyses to which will help us to learn more about the factors that cause various cardiovascular diseases such as coronary heart disease, angina, heart failure, hypertension, and stroke. The statistical analyses will also help us to understand how these diseases can be treated more effectively.

How the Research Will Advance Scientific Knowledge/Human Health:

By collecting a large amount of data on a large number of cardiovascular patients, we will be able to analyze, with a great deal of precision, those factors that influence the onset, course, and treatment of cardiovascular disease. The results of these precise analyses can then be used to help optimize clinical efforts to prevent and treat cardiovascular disease.


Condition
Cardiovascular Disease

Study Type: Observational
Study Design: Observational Model: Ecologic or Community
Time Perspective: Cross-Sectional
Official Title: Cardiology Biobank Registry

Further study details as provided by Arshed A. Quyyumi, Emory University:

Primary Outcome Measures:
  • All cause death [ Time Frame: Continuous ]

Secondary Outcome Measures:
  • Cardiovascular death [ Time Frame: Continuous ]
  • Re-hospitalization for heart failure [ Time Frame: Continuous ]

Other Outcome Measures:
  • Myocardial Infarction [ Time Frame: Continuous ]
  • Stroke [ Time Frame: Continuous ]

Biospecimen Retention:   Samples With DNA
60 cc of blood will be obtained from the participant. Blood will be processed and stored in -80F freezers as plasma, serum, extracted DNA and whole blood.

Estimated Enrollment: 12000
Study Start Date: December 2003
Estimated Study Completion Date: April 2020
Estimated Primary Completion Date: March 2020 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
General population & patients presenting to the hospital
Criteria

Inclusion Criteria:

  • 18 & Older

Exclusion Criteria:

  • Congenital Heart Disease
  • Recent Blood Transfusion (less than a month)
  • Moderate to Severe Anemia
  • Active cancer
  • Physician request for patient not to be included in study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00378924


Contacts
Contact: Ayman J Tahhan, MD 404 712 0168 ayman.tahhan@emory.edu
Contact: Salman Sher, MD 404 412 0170 ssher2@emory.edu

Locations
United States, Georgia
Emory School Of Medicine Recruiting
Atlanta, Georgia, United States, 30322
Contact: Ayman J Tahhan, MD    404-712-0168    ayman.tahhan@emory.edu   
Contact: Salman Sher, MD    404 712 0170    ssher2@emory.edu   
Principal Investigator: Arshed A Quyyumi, MD         
Sponsors and Collaborators
Emory University
Investigators
Principal Investigator: Arshed A Quyyumi, MD Emory School Of Medicine
  More Information

Responsible Party: Arshed A. Quyyumi, Professor, Emory University
ClinicalTrials.gov Identifier: NCT00378924     History of Changes
Other Study ID Numbers: IRB00000343
950-2003 ( Other Identifier: Other )
First Submitted: September 19, 2006
First Posted: September 21, 2006
Last Update Posted: July 26, 2017
Last Verified: July 2017

Additional relevant MeSH terms:
Cardiovascular Diseases