Tranexamic Acid vs. Quixil - Reducing Blood Loss in Joint Replacement
Arthroplasty, Replacement, Hip
Arthroplasty, Replacement, Knee
Drug: IV Tranexamic acid 10mg/kg pt body weight
Drug: Quixil topical sealant
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Prevention
|Official Title:||Prospective Randomised Trial Comparing Intraoperative Topical Quixil and Intravenous Tranexamic Acid, in Reduction of Blood Loss Following Primary Hip & Knee Joint Replacement Surgery.|
- Blood loss as calculated from change in haematocrit
|Study Start Date:||June 2006|
|Study Completion Date:||May 2008|
|Primary Completion Date:||May 2008 (Final data collection date for primary outcome measure)|
This is a prospective randomised controlled trial to compare the benefits of Quixil vs. Tranexamic acid in reducing blood loss.
Both medicines are used for the reduction of blood loss in major joint surgery; previous studies have shown each one to be effective and safe, but they have not been directly compared in this setting.
We will compare the blood loss in each of 3 groups: tranexamic acid used, Quixil used, and control group (neither drug used). Blood loss is to be calculated from height, body weight and difference between pre and post-operation haematocrit.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00378872
|Golden Jubilee National Hospital|
|Clydebank, Scotland, United Kingdom, G81 4HX|
|Principal Investigator:||Jamie S McConnell, MB BCh MRCS||Golden Jubilee National Hospital, NHS Scotland|