The Effect of Milk and Meat on IGFs in Prepubertal Boys
|Growth Disorders Metabolic Syndrome||Behavioral: Skim milk Behavioral: Lean meat|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
|Official Title:||The Effect of Milk and Meat on IGFs in Prepubertal Boys|
- Blood Pressure
- Kidney Size
- Urea Nitrogen
|Study Start Date:||November 2000|
|Estimated Study Completion Date:||March 2001|
The objective of the study is to examine whether a high protein intake (PI) from either milk or meat, at a level often seen in late infancy, in healthy, prepubertal children can increase fasting levels of serum IGF-I, IGFBP-3 and IGF-I/IGFBP-3 as well as insulin, glucose and HOMA insulin reststance, HOMA beta cell function and amino acids.
IGF-I levels are positively associated with growth velocity in children and some studies suggest that a high animal PI can stimulate growth. During protein deprivation IGF-I decrease, but it is unknown whether a high PI can increase s-IGF-I in well-nourished children.
Insulin is also a growth factor, and studies have found that postprandially, milk possess some insulinotrophic effect not related to its carbohydrate content. However, the effect on fasting insulin in children is unknown.
Design: Twenty-four 8-y-old boys are asked to take either 1.5 l of skimmed milk (n=12) or the same amount of protein as 250 g low fat meat (n=12) daily for seven days. The remaining diet they can choose freely. At baseline and after seven days, anthropometrical variables are measured, diet is registered (3-d weighed records), and the blood analytes are determined after fast.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00378859
|Institute of Human Nutrition, Rolighedsvej 30|
|Frederiksberg C, Denmark, 1958|
|Study Chair:||Kim F Michaelsen, Dr Med Sci||Institute of Human Nutrition, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark|