The Effect of Milk and Meat on IGFs in Prepubertal Boys
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|ClinicalTrials.gov Identifier: NCT00378859|
Recruitment Status : Completed
First Posted : September 21, 2006
Last Update Posted : January 21, 2009
|Condition or disease||Intervention/treatment||Phase|
|Growth Disorders Metabolic Syndrome||Behavioral: Skim milk Behavioral: Lean meat||Not Applicable|
The objective of the study is to examine whether a high protein intake (PI) from either milk or meat, at a level often seen in late infancy, in healthy, prepubertal children can increase fasting levels of serum IGF-I, IGFBP-3 and IGF-I/IGFBP-3 as well as insulin, glucose and HOMA insulin reststance, HOMA beta cell function and amino acids.
IGF-I levels are positively associated with growth velocity in children and some studies suggest that a high animal PI can stimulate growth. During protein deprivation IGF-I decrease, but it is unknown whether a high PI can increase s-IGF-I in well-nourished children.
Insulin is also a growth factor, and studies have found that postprandially, milk possess some insulinotrophic effect not related to its carbohydrate content. However, the effect on fasting insulin in children is unknown.
Design: Twenty-four 8-y-old boys are asked to take either 1.5 l of skimmed milk (n=12) or the same amount of protein as 250 g low fat meat (n=12) daily for seven days. The remaining diet they can choose freely. At baseline and after seven days, anthropometrical variables are measured, diet is registered (3-d weighed records), and the blood analytes are determined after fast.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||24 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effect of Milk and Meat on IGFs in Prepubertal Boys|
|Study Start Date :||November 2000|
|Study Completion Date :||March 2001|
- Blood Pressure
- Kidney Size
- Urea Nitrogen
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00378859
|Institute of Human Nutrition, Rolighedsvej 30|
|Frederiksberg C, Denmark, 1958|
|Study Chair:||Kim F Michaelsen, Dr Med Sci||Institute of Human Nutrition, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark|