Study of the Effects of Muscular Activity on Iron Metabolism
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00378469|
Recruitment Status : Unknown
Verified May 2007 by Rennes University Hospital.
Recruitment status was: Recruiting
First Posted : September 20, 2006
Last Update Posted : July 12, 2007
|Condition or disease||Intervention/treatment||Phase|
|Iron Overload Iron Deficiency||Behavioral: 45 minute exercise on ergocycle||Not Applicable|
Hemojuvelin has been described as interfering with hepcidin, a key regulator of iron homeostasis. Hemojuvelin is mainly produced by muscle, and the relationship between exercise and iron metabolism can be questioned about.
The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will be investigated at two periods according to a cross-over design after:
- 45 minutes of exercise on the ergocycle; and
- no physical exercise.
Urine and blood samples will be collected at both periods regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||14 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Study of the Effects of Muscular Activity on Iron Metabolism: A Pilot Study on Healthy Volunteers|
|Study Start Date :||September 2006|
- Pharmacokinetics of urinary hepcidin
- Pharmacokinetics of blood hemojuvelin
- Pharmacokinetics of urine and blood iron, transferrin, interleukin-6 (IL-6) and ferritin
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00378469
|Contact: Pierre Brissot, MDemail@example.com|
|Contact: Fabrice Lainé, MDfirstname.lastname@example.org|
|Service des Maladies du Foie - Hôpital de Pontchaillou||Recruiting|
|Rennes, France, 35033|
|Contact: Pierre Brissot, MD 33-2-9928-4297 email@example.com|
|Principal Investigator: Pierre Brissot, MD|
|Sub-Investigator: Yves Deugnier, MD|
|Sub-Investigator: Fabrice Lainé, MD|
|Unité de Biologie et Médecine du Sport - Hôpital de Pontchaillou||Recruiting|
|Rennes, France, 35033|
|Contact: Pierre Rochcongar, MD 33-2-9928-9323 firstname.lastname@example.org|
|Principal Investigator: Pierre Rochcongar, MD|
|Sub-Investigator: Jocelyne Beillot, MD|
|Principal Investigator:||Pierre Brissot, MD||Rennes University Hospital|
|Study Chair:||Bruno Laviolle, MD||Rennes University Hospital|