Study of the Effects of Muscular Activity on Iron Metabolism
Recruitment status was Recruiting
The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will have to pedal on an ergocycle for 45 minutes, and urine and blood samples will be collected regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.
|Study Design:||Allocation: Randomized
Endpoint Classification: Pharmacokinetics/Dynamics Study
Intervention Model: Crossover Assignment
Masking: Open Label
|Official Title:||Study of the Effects of Muscular Activity on Iron Metabolism: A Pilot Study on Healthy Volunteers|
- Pharmacokinetics of urinary hepcidin
- Pharmacokinetics of blood hemojuvelin
- Pharmacokinetics of urine and blood iron, transferrin, interleukin-6 (IL-6) and ferritin
|Study Start Date:||September 2006|
Hemojuvelin has been described as interfering with hepcidin, a key regulator of iron homeostasis. Hemojuvelin is mainly produced by muscle, and the relationship between exercise and iron metabolism can be questioned about.
The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will be investigated at two periods according to a cross-over design after:
- 45 minutes of exercise on the ergocycle; and
- no physical exercise.
Urine and blood samples will be collected at both periods regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00378469
|Contact: Pierre Brissot, MDfirstname.lastname@example.org|
|Contact: Fabrice Lainé, MDemail@example.com|
|Service des Maladies du Foie - Hôpital de Pontchaillou||Recruiting|
|Rennes, France, 35033|
|Contact: Pierre Brissot, MD 33-2-9928-4297 firstname.lastname@example.org|
|Principal Investigator: Pierre Brissot, MD|
|Sub-Investigator: Yves Deugnier, MD|
|Sub-Investigator: Fabrice Lainé, MD|
|Unité de Biologie et Médecine du Sport - Hôpital de Pontchaillou||Recruiting|
|Rennes, France, 35033|
|Contact: Pierre Rochcongar, MD 33-2-9928-9323 email@example.com|
|Principal Investigator: Pierre Rochcongar, MD|
|Sub-Investigator: Jocelyne Beillot, MD|
|Principal Investigator:||Pierre Brissot, MD||Rennes University Hospital|
|Study Chair:||Bruno Laviolle, MD||Rennes University Hospital|