Vitamins and Minerals for Children With Downs Syndrome
The trial aimed to examine the effects of supplementation with antioxidants and folinic acid on the health, growth and psychomotor development of children with Down syndrome. 156 children with Trisomy 21, less than 7 months of age were recruited and randomised into four groups to receive antioxidants, folinic acid, a combination of antioxidants and folinic acid or a placebo. Blinded outcome assessment was carried out 18 months later.Blood and urine samples were also taken around 12 months of age to examine metabolic effects of supplementation.
Trisiomy 21 (Down Syndrome)
Drug: Antioxidants- (Vitamins A,C,E Selenium and Zinc)
Drug: Folinic acid
Drug: Vitamins A,C,E Selenium and Zinc and Folinic acid.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Please refer to this study by its ClinicalTrials.gov identifier: NCT00378456
|Institute of Child Health|
|Birmingham, United Kingdom|
|Peninsular Medical School|
|Exeter, United Kingdom|
|Institute of Child Health, London|
|London, United Kingdom|
|Principal Investigator:||Stuart Logan||Peninsular Medical School, Exeter|