Vitamins and Minerals for Children With Downs Syndrome
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The trial aimed to examine the effects of supplementation with antioxidants and folinic acid on the health, growth and psychomotor development of children with Down syndrome. 156 children with Trisomy 21, less than 7 months of age were recruited and randomised into four groups to receive antioxidants, folinic acid, a combination of antioxidants and folinic acid or a placebo. Blinded outcome assessment was carried out 18 months later.Blood and urine samples were also taken around 12 months of age to examine metabolic effects of supplementation.
Condition or disease
Trisiomy 21 (Down Syndrome)
Drug: Antioxidants- (Vitamins A,C,E Selenium and Zinc)Drug: Folinic acidDrug: Vitamins A,C,E Selenium and Zinc and Folinic acid.Drug: Placebo
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Ages Eligible for Study:
up to 7 Months (Child)
Sexes Eligible for Study:
Under 7 months of age
Live in recruitment Area-i.e. London inside M25, in West Midlands or SW England.